ID   A0A1G5C868_9FIRM        Unreviewed;      1075 AA.
AC   A0A1G5C868;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:SCX98494.1};
GN   ORFNames=SAMN02910371_00662 {ECO:0000313|EMBL:SCX98494.1};
OS   Butyrivibrio sp. INlla14.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio.
OX   NCBI_TaxID=1520808 {ECO:0000313|EMBL:SCX98494.1, ECO:0000313|Proteomes:UP000199551};
RN   [1] {ECO:0000313|Proteomes:UP000199551}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=INlla14 {ECO:0000313|Proteomes:UP000199551};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; FMVS01000004; SCX98494.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G5C868; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000199551; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199551}.
FT   DOMAIN          551..629
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1075 AA;  122804 MW;  4A9D35425E32082F CRC64;
     MDNRLEQIES FANRLKTQMF GLRTDITTVM DGAGIRHKKV GYGQRKELLG DCLNWEEFSN
     GGLWGEPDGH DLFRVKVVIP EEFSGREVFF FLSTGADDIW NTDNPQMLVY INGIRRSGMD
     MNHNSVCIYD VDDWKKGTDR VVDIAIYGYS NLSQNSNYLK MELAALDEVS KNAFYDISVA
     FGAAKAMLGL DSRKNAIDLL SDKKAIESVQ PVDVLHAETI LNILMEAVKA LKPAKSGAGY
     AEESMTDMSA FLHKNLYGTE KSDQIVASTG HTHIDVAWKW PIRQTREKVI RSYSTVMELM
     KRYPEYLFMA STPQMYEFVR EDEPELFEEI KERVKEGRFE PEGAMWLEAD CNLTSGESLV
     RQILYGKRYF QEVFGVNSHI LWLPDVFGYS AAMPQIMKKS GIKAFVTTKL AWNDTNRMPH
     DLFMWKGIDG SMVPTYLITT CDLPRADLVM KEGGILNYTY NGRQDASQIM GTWRAFREKD
     ITDETLTVYG FGDGGGGPIW EMLEQDRRLR EGIPGCPVTV QKSVTEFMDG LLEKVSKSDN
     VPVWEDELYL EFHRGTYTSM GKNKRYNRRL EHLLKEAEIL LTYAHLEAGL EYPAKELMEA
     WKILMLNQFH DILPGSSIEE VYQVSEEDYK RGIHIVEELI KRAILVFNIT DKESDKKAVK
     KSTNGIIIRG ASEGVRGLKI ETNYYVISFD EKGEIISLYD KEIGGEIRDM TQTSLNRLIA
     FKDEPLEYDA WNIDANFEDI SFDITDLSEI SVLTYKKDGS FVDISETVFG EESSGLDGDF
     CELHLKLLRK FCSSTISQTI VIRNDERRID FRTKADWHEH QILLKAAFPV NIDSREITCE
     IQYGDIKRNL SRDNSWDRAK FECCAHRWMD ISDRNGGNYG VAVLNDCKYG YDAKEKLMRL
     TLIKSGIFPN PNADQGEHEF TYSLLPHPGD HREGNIIEEA EALNGESHYY VPKNDSLSSI
     LGEEKRSAYN LVKDIEKAVI DLGDSQGVYI DAIKLAEDSG DIIIRLHEGH GRSRQVNAIL
     FSNIRRDISI AEVYECDLLE KRLSEAAMRY FDADKKLSLY MEAYEIKTIR IVING
//