ID A0A1G5EUU8_9PROT Unreviewed; 714 AA.
AC A0A1G5EUU8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:SCY30747.1};
GN ORFNames=SAMN05216308_10787 {ECO:0000313|EMBL:SCY30747.1};
OS Nitrosospira sp. Nsp13.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosospira.
OX NCBI_TaxID=1855332 {ECO:0000313|EMBL:SCY30747.1, ECO:0000313|Proteomes:UP000198731};
RN [1] {ECO:0000313|EMBL:SCY30747.1, ECO:0000313|Proteomes:UP000198731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nsp13 {ECO:0000313|EMBL:SCY30747.1,
RC ECO:0000313|Proteomes:UP000198731};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; FMVD01000007; SCY30747.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5EUU8; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000198731; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:SCY30747.1};
KW Transferase {ECO:0000313|EMBL:SCY30747.1}.
FT DOMAIN 57..156
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 398..459
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 641..714
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 714 AA; 79547 MW; A9CB3D1A73B93909 CRC64;
MRARGLPDPS ATLPEADFLF GELSGYLKPE DISELQNAYL FSQSAHSGQF RKSGEPYISH
PLAVAGILGK LRLDPQTLTA ALLHDVMEDT HVSKAEISDR FGKPVAELVD GVSKLDKIEF
QTHADAQAEN FRKMLLAMAR DVRVILIKLA DRLHNMRTLE AMRPEKRRRI ARETMEIYAP
IANRLGLNNI YQELQELSFR YLFPTRYRVL TNATKAARGN RREVVTKILD SIKQRLQAAG
LDAEVTGREK QLYSIYKKMA EKHLTFSEVL DIYGFRVIVK DVPSCYIALG ALHSLYNPIP
GKFKDYIAIP KANGYQSLHN TLWGPYGTPI EVQIRTADMH RIAEAGVASH WLYKSTDADL
NDLHMKTHQW LQSLLETLSD STDSLEFLEH LKVDLFPGEV YVFTPQGKIL ALPKDATAVD
FAYAVHTDIG DCCVAAKING ENAPLRTHLR SGDRVEIVTA SHAKPNPAWL NYVVTGKARS
HIRRFLKTMQ YEESAKLGER LLNQALMSLK IDPQTISETQ WEKLARESSA KSKKDLLADM
GLGMHLPAVI ARRLASPGES ASGANGGNGV ITILGTEGMA VQFAKCCRPI PGDPIVGFIK
KDQGLVIHIH DCPVISKNRG NSDNWLDVAW GKGIARHFEV SIRTVVANQR GVLARVAAAI
AEAGSNIDNV VMEGDGAYTT MNFMLQVRNR YHLAQVMRSL RRIPEVAKIT RMKG
//
