ID A0A1G5GEV9_9PROT Unreviewed; 385 AA.
AC A0A1G5GEV9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=SAMN05216308_11367 {ECO:0000313|EMBL:SCY49800.1};
OS Nitrosospira sp. Nsp13.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosospira.
OX NCBI_TaxID=1855332 {ECO:0000313|EMBL:SCY49800.1, ECO:0000313|Proteomes:UP000198731};
RN [1] {ECO:0000313|EMBL:SCY49800.1, ECO:0000313|Proteomes:UP000198731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nsp13 {ECO:0000313|EMBL:SCY49800.1,
RC ECO:0000313|Proteomes:UP000198731};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; FMVD01000013; SCY49800.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5GEV9; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000198731; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF25; CITRATE SYNTHASE-RELATED PROTEIN DDB_G0287281; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 270
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 321
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 385 AA; 42539 MW; B6B82AC759AA7950 CRC64;
MSEVIQNPGL KGKKSVTLSG VVAGNTAICS VGRTGNDLHY RGYDILDVAD TCEFEEIAYL
LIHEKLPTLA ELAAYKEKLR RLRDLPVGLK TVLETIPVTA HPMDVLRTGV AALGTMLPEA
EKHTVEGARD LADRLLACLG PLLLYWYHYS HNNRRIDVAT SEDSIGGNFL SLLHGKPPPQ
SWVKAMHTSL LLYAEHEFNA STFTARVIAG TGSDFYSSIT GAIGALRGSK HGGANEAAFD
IQKRYDTPDK AEADIRCRVA DKEIIIGFGH PVYTVSDPRN RIIREVARQL SAEAGDMKMF
DVAARLETVM WDIKKMFPNL DWFSAVSYHM MGIPTAMFTP LFAIARTSGW AAHIIEQRLD
NKIIRPSANY IGPEDREFVP ISARA
//
