ID A0A1G5I9F3_9FLAO Unreviewed; 855 AA.
AC A0A1G5I9F3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN02927903_02160 {ECO:0000313|EMBL:SCY72280.1};
OS Flavobacterium caeni.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=490189 {ECO:0000313|EMBL:SCY72280.1, ECO:0000313|Proteomes:UP000199354};
RN [1] {ECO:0000313|EMBL:SCY72280.1, ECO:0000313|Proteomes:UP000199354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.7031 {ECO:0000313|EMBL:SCY72280.1,
RC ECO:0000313|Proteomes:UP000199354};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FMVF01000009; SCY72280.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5I9F3; -.
DR STRING; 490189.SAMN02927903_02160; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000199354; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000199354}.
FT DOMAIN 681..697
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 855 AA; 95897 MW; F86E74C7EFB23D36 CRC64;
MKQYNEIKRK YPDACLLFRV GDFYETFGED AIRASKILGI TLTKRGNGSE SETALAGFPH
HSLNTYLPKL VKAGLRVAVC DQLEDPKMTK TIVKRGVTEL VTPGVALNDE VLQSKSNNFL
ASVHFGKKLI GISFLDVSTG EFLTAQGNEE YIDKLLQNFR PSEVLVPKAH KGQFKSFFGD
DFHTFLLEDW IYKQDYAEES LTKHFGTNSL KGFGIEDLAE GVVSSGAILY YLSETQHNKL
QHIASIQRIA EDAYVWMDRF TIRNLELYHS YNPNAVTLLD VIDRTLSPMG GRLLKRWLAL
PLKDRSRIVE RHELVGYLKD HKNVLQNIQQ QIKRMADLER LISKIATGKV SPREVVSLKE
SLDAIAPIKA LALGSDHPSV KAFGERLHDC AMLREKIAAT LNPEAPVAIA KGNAIAQGVH
PELDELRAIS TSGKNFLEGI EKSESERTGI SSLKISFNNV FGYYIEVRNT HKDKVPAEWI
RKQTLVNAER YITEELKEYE SKILGAEEKI YKLEVELFEQ LVAWLSGYIK QVQANAQLVA
QLDCLASFAQ LAIENKYVCP ELTDDFALDI KNGRHPVIEK QLPVGTPYIA NDVLLDRENQ
QIIMITGPNM SGKSAILRQT ALIVLLAQMG SFVPAESVTM GVVDKIFTRV GASDNISMGE
STFMVEMNET ASILNNISDR SLVLLDEIGR GTSTYDGISI AWAIAEFLHE HPARPKTLFA
THYHELNEMS DIFGRVKNFN VAVKEMKDTV LFIRKLVQGG SAHSFGIHVA KMAGMPQTVI
SRAQKLLKKL EKDHSGEALN GVKEEKQELQ MSFFNLDDPL LEEIKEEILG LDLNTLTPIE
AMMKLNEIKR MLTKK
//
