ID A0A1G5K601_9CLOT Unreviewed; 545 AA.
AC A0A1G5K601;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Radical SAM superfamily enzyme YgiQ, UPF0313 family {ECO:0000313|EMBL:SCY96052.1};
GN ORFNames=SAMN03080606_03248 {ECO:0000313|EMBL:SCY96052.1};
OS Alkaliphilus peptidifermentans DSM 18978.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Alkaliphilus.
OX NCBI_TaxID=1120976 {ECO:0000313|EMBL:SCY96052.1, ECO:0000313|Proteomes:UP000198636};
RN [1] {ECO:0000313|EMBL:SCY96052.1, ECO:0000313|Proteomes:UP000198636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18978 {ECO:0000313|EMBL:SCY96052.1,
RC ECO:0000313|Proteomes:UP000198636};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FMUS01000024; SCY96052.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5K601; -.
DR STRING; 1120976.SAMN03080606_03248; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000198636; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF12; BLL1977 PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000198636}.
FT DOMAIN 3..137
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 175..408
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 545 AA; 62862 MW; 751042A8E22F00C5 CRC64;
MKKLRILLFA LYCDGMWQIH EEIGICYIAS YLRKYGYEVI LKSIEVNSIN YSQLAELNPD
VIGIPVYDAN KKGVYEACIQ LRRLLPETVI SIGGSVPTCY GIDVLKECRE IDIAIKGEGE
LTFLELLTKL ESNSSLDKVK GIIYREGSNI VENETRPLID NMDNLPFPSR DILKEMDIKV
AQISTSRGCT ANCSFCASKL YWTKWRGRSV DSVVDEMQYI VNNYGIRAFN IIDGSFEDPG
NDFNRIYSIA QGILDRGLVI TYYVHMRAEF FNRAPADLIQ LLKKSGLVTV CIGLESADAE
DLKLYNKNAT LNEIEKAIEV LQQHDINVDP GFINFNPYTT FQKLKKNIDF LERHGFASNP
DYIIKSSRIY RGTTLHKRAS RDNLLRDEEV YECGFYFADT RIKDLYEYTF LHLKGVDPVD
VSIFRGICHG SSFNNVGISC MKKLLLKYSL NEAYEIVKDY ENECRNISSH INKSIALWFR
EIIKLAEEGW DKGQAEEISF KYLPKQYLKD IVRSFQYQNE RLRKQLFKLD MDKGFVGLLK
YILQY
//
