ID   A0A1G5KMF8_9BACL        Unreviewed;       629 AA.
AC   A0A1G5KMF8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Homocysteine S-methyltransferase {ECO:0000313|EMBL:SCZ01843.1};
GN   ORFNames=SAMN05720606_11622 {ECO:0000313|EMBL:SCZ01843.1};
OS   Paenibacillus polysaccharolyticus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=582692 {ECO:0000313|EMBL:SCZ01843.1, ECO:0000313|Proteomes:UP000198538};
RN   [1] {ECO:0000313|EMBL:SCZ01843.1, ECO:0000313|Proteomes:UP000198538}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL9 {ECO:0000313|EMBL:SCZ01843.1,
RC   ECO:0000313|Proteomes:UP000198538};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU00333};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777}.
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DR   EMBL; FMVM01000016; SCZ01843.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G5KMF8; -.
DR   STRING; 582692.SAMN05720606_11622; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000198538; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003726; HCY_dom.
DR   InterPro; IPR036589; HCY_dom_sf.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   PANTHER; PTHR11103:SF18; HOMOCYSTEINE S-METHYLTRANSFERASE 1-RELATED; 1.
DR   PANTHER; PTHR11103; SLR1189 PROTEIN; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   Pfam; PF02574; S-methyl_trans; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
DR   SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR   PROSITE; PS50970; HCY; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00333};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}; Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00333}.
FT   DOMAIN          2..285
FT                   /note="Hcy-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50970"
FT   BINDING         205
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         270
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT   BINDING         271
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ   SEQUENCE   629 AA;  68845 MW;  7C2263FA021AC3D4 CRC64;
     MKADLRTAMK QRVLVGDGAM GTFLYQMGFP VGISYEELNL ISPEVVADVH RRYRDAGTDI
     FETNTYSANF DKLSKFGLES KVEDVNRAGV RIAKEVAGAE GYVLGAVGSI RGGKRTNVST
     SELKRFYQQQ IFALLDEGVD GILLETFYDI EEMDIALLQA RKLSDLPVIG QFAVEDVGHT
     LDGYTMPEAF RIMREQGADV IGFNCRSGPN GIMRAMETVS GRIGVPMSVY PNAGAADYVD
     GQFRYGATPE YFGQTAIQFA DLGARIIGGC CGTTPDHITA IKEALADYVP QPIAEPYPAE
     ITSRIVLHEN VDERAGRGGQ PTIVDLVKQR HTVIVELDPP RDLDIAKFMK GAETLKAAGA
     DALTLADNSL AVTRMSNMAL GHLVQDRTGL RALVHIACRD RNLIGTQSHM MGFDALGINH
     VLAVTGDPAR FGDLPGSSSV YDLTSFEIIR MIKQLNDGVA FSGKPLKQKA GFVIGAAFNP
     NVKHLDKAVQ RLEKKIASGA DYIMTQPVYD PELIVAMREA TKHLDIPIFI GIMPLASGRN
     AEYLHNEVPG IQLSDEVRSR MAGLEGEEGR AMGVTIAKEL LDVATEHFKG IYLMTPFMFY
     GMTAELTQYV WEKSEHQCPT CFNPNNQLQ
//