ID A0A1G5KS44_9ACTN Unreviewed; 555 AA.
AC A0A1G5KS44;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN02745898_10717 {ECO:0000313|EMBL:SCZ02920.1};
OS Streptomyces sp. 136MFCol5.1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1172182 {ECO:0000313|EMBL:SCZ02920.1, ECO:0000313|Proteomes:UP000199326};
RN [1] {ECO:0000313|EMBL:SCZ02920.1, ECO:0000313|Proteomes:UP000199326}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=136MFCol5.1 {ECO:0000313|EMBL:SCZ02920.1,
RC ECO:0000313|Proteomes:UP000199326};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FMVI01000007; SCZ02920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5KS44; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000199326; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SCZ02920.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199326};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SCZ02920.1}.
FT DOMAIN 19..228
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 287..517
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 527..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 57662 MW; 08CD0997E002D024 CRC64;
MSPTGPAASD FPVLPAGHVT FLGAGPGDPG LLTLRAVEAL ASADVLVAEP DVLGVVRGHA
RAGVSTPELA VVDVSSTAAG VPVLRDAANL VMEAAKGGRR VVRAVSGDPG LDGAAGSEML
ACAAAGIPFE VVPGVANGVG VPAYAGVPLR DAQGADVRFV DARTASDRCW TEIGASDATA
VVSTTLDSVA ATAGELVSAG RKPDTPLTVT VAGTTTRQRT WTATLGTIAQ VLKQAKVLPS
PDGHQPVIAV VGERSSAAQR DQLSWFESKP LFGWKVLVPR TKEQAASLSD QLRSYGAVPH
EVPTIAVEPP RTPQQMERAV KGLVTGRYEW IAFTSVNAVK AVREKFEEYG LDARAFAGIK
VAAVGEQTAA ALIDFGVKPD LVPSGEQSAA GLLEDWPPYD PVFDPIDRVF LPRADIATET
LVAGLIELGW EVDDVTAYRT VRASPPPSDT REAIKGGGFD AVLFTSSSTV RNLVGIAGKP
HNVTVIACIG PATAKTAEEH GLRVDVLSPE PSVHKLAAAL ADFGAQRRDA AKEAGDPVTR
PSERRPGARR RRTTT
//
