ID A0A1G5KW64_9ACTN Unreviewed; 406 AA.
AC A0A1G5KW64;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:SCZ04855.1};
GN ORFNames=SAMN02745898_107265 {ECO:0000313|EMBL:SCZ04855.1};
OS Streptomyces sp. 136MFCol5.1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1172182 {ECO:0000313|EMBL:SCZ04855.1, ECO:0000313|Proteomes:UP000199326};
RN [1] {ECO:0000313|EMBL:SCZ04855.1, ECO:0000313|Proteomes:UP000199326}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=136MFCol5.1 {ECO:0000313|EMBL:SCZ04855.1,
RC ECO:0000313|Proteomes:UP000199326};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; FMVI01000007; SCZ04855.1; -; Genomic_DNA.
DR RefSeq; WP_030926900.1; NZ_FMVI01000007.1.
DR AlphaFoldDB; A0A1G5KW64; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000199326; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000199326};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SCZ04855.1}.
FT DOMAIN 5..274
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 361
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 391
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 406 AA; 42764 MW; 84A87F82084FA7C8 CRC64;
MPEAVIVSAA RSPIGRAFKG SLKDLRADDL TATIIQTALA KVPELDPRDI DDLMLGCGLP
GGEQGNNLGR IIAVQMGMDH LPGCTVTRYC SSSLQTSRMA LHAIKAGEGD VFISAGVEMV
SRFVKGNSDS LPDTHNPLFA EAEARTAARA EETGASWHDP REDGLVPDAY IAMGQTAENL
ARLKGVTRQD MDEFGVRSQN LAEEAIKNGF WAREITPVTT PDGTVVSQDD GPRAGVTLEG
VQGLKPVFRP DGLVTAANCC PLNDGAAALV IMSDTKAREL GLTPLARIVS TGVSGLSPEI
MGYGPVEASK QALKRAGLTI DDIDLAEINE AFAAQVIPSY RDLGLPLEKV NVNGGAIAVG
HPFGMTGARI TGTLINSLQF HDKQFGLETM CVGGGQGMAM VIERLS
//
