ID A0A1G5Q058_9MICC Unreviewed; 845 AA.
AC A0A1G5Q058;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN ORFNames=SAMN02799638_01691 {ECO:0000313|EMBL:SCZ55235.1};
OS Arthrobacter sp. UNCCL28.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=1502752 {ECO:0000313|EMBL:SCZ55235.1, ECO:0000313|Proteomes:UP000199526};
RN [1] {ECO:0000313|EMBL:SCZ55235.1, ECO:0000313|Proteomes:UP000199526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNCCL28 {ECO:0000313|EMBL:SCZ55235.1,
RC ECO:0000313|Proteomes:UP000199526};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
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DR EMBL; FMWE01000002; SCZ55235.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5Q058; -.
DR STRING; 1502752.SAMN02799638_01691; -.
DR Proteomes; UP000199526; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 72..360
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 361..650
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 22..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 93..100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 845 AA; 91385 MW; 1D8EA6352AD3F1D4 CRC64;
MLFDPYADGP FKAGTKAAVK AAPELSRPGG GIAGARVQGG SGGSSDTAGG SASGGWGNSG
GSGLPSAEAL LQGLNPQQEE AVKHAGTPLL IVAGAGSGKT RVLSNRIAYL IATKRAHHGE
ILAITFTNKA AAEMRERIEA LVGGRAKAMW ISTFHSSCVR ILRREATTVG LNSNFSIYDS
ADSLRLITLV SKNLDLDPKK FAPKAIQHKI SALKNELIDA DSYASTANYN DPFDTAVAEV
FKGYTQRLRQ ANAMDFDDLI AETVYMFRAF PALAESYRRR FRHVLVDEYQ DTNHAQYALV
REIVGVGTDT SVQPSELTVV GDSDQSIYAF RGADIRNIVE FEADYPNART IKLEQNYRST
QNILSAANSV ISRNPNRQEK RLWTAEGDGE KIIGYVGENE HDEAQFIAKE IDRLQDEEGL
RPGDVAIFYR TNAQSRSIED VLVRVGLPYK VVGGTRFYER KEIKDALAYL RVLVNPDDDV
NLRRILNEPK RGIGDRAEGA VAALAERERS SFMAAARRAD QAPGMASRSV NLVLGFVKLM
DDLAEVASGS GAAAALEAVL EQTGYLAGLR ASTDPQDESR VENLAELVAV VREYERDNPE
GSLGEFLEQV SLVADADQIP DAPGADIDAA VAEAKRMGVV TLMTLHTAKG LEFPVVFLTG
MEHGIFPHQR SATDPKELAE ERRLAYVGLT RARKRLYVTR SEVRSMWGQS QYNPASQFLE
EIPSGLVEWK REGMSRQAGG WGSAPIGSNR YGGSFWGAGT SRGAAASPTA GFDADVPAAV
ARNRVQPQKE VISVVVGDKV NHTSFGNGVV LGVEGAGDKT VAKVKFDVGE KRLLLRYAPL
TKLDA
//
