ID   A0A1G5SN88_9SPHN        Unreviewed;       345 AA.
AC   A0A1G5SN88;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:SDA10520.1};
GN   ORFNames=SAMN03159340_00018 {ECO:0000313|EMBL:SDA10520.1};
OS   Sphingomonas sp. NFR15.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1566282 {ECO:0000313|EMBL:SDA10520.1, ECO:0000313|Proteomes:UP000199327};
RN   [1] {ECO:0000313|Proteomes:UP000199327}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NFR15 {ECO:0000313|Proteomes:UP000199327};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR   EMBL; FMWX01000001; SDA10520.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G5SN88; -.
DR   STRING; 1566282.SAMN03159340_00018; -.
DR   OrthoDB; 9808822at2; -.
DR   Proteomes; UP000199327; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR012824; CobW.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR02475; CobW; 1.
DR   PANTHER; PTHR13748; COBW-RELATED; 1.
DR   PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199327}.
FT   DOMAIN          253..345
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
SQ   SEQUENCE   345 AA;  36367 MW;  B09E653638D0F52C CRC64;
     MSDLSKVPVT IVTGFLGAGK TTLISHLIRQ AGGRRLAVVV NEFGTLGVDG DILKGCAIPD
     CPAENIVELA NGCICCTVAD DFIPTVEMLL ALDPRPDHIL IETSGLALPK PLLKAFDWPA
     IRSRITVDGV IALADAEAVA AGRFAPDVTA LDAQRAADPS IDHETPLSEV FEDQLGCADL
     VLLTKCDLAG AEGIATARAV IAAETRKPLP VIELVDGVVD PRVVLGLGAA AEDDIAARPS
     HHDGEEEHEH DDFDSIVIEQ GDIVAPDDLA GRIEAIGASG DVLRVKGYAA VAGKPMRLLV
     QAVGARVRTH YDRPWGVDEP RLTRLVVIAE RDRLDPAAIR AALTA
//