ID A0A1G5UR27_9SPHN Unreviewed; 1038 AA.
AC A0A1G5UR27;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN03159340_03303 {ECO:0000313|EMBL:SDA35556.1};
OS Sphingomonas sp. NFR15.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1566282 {ECO:0000313|EMBL:SDA35556.1, ECO:0000313|Proteomes:UP000199327};
RN [1] {ECO:0000313|Proteomes:UP000199327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NFR15 {ECO:0000313|Proteomes:UP000199327};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; FMWX01000007; SDA35556.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5UR27; -.
DR STRING; 1566282.SAMN03159340_03303; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000199327; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SDA35556.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000199327}.
FT DOMAIN 527..687
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 708..862
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1038 AA; 110800 MW; A7E061DB900956DB CRC64;
MNLAFTAFRL AEMLAEPDVV FLADDEQQAE ALAAALGALL SDDRVIFVPS SDALPGDSSP
ASPANTGKRV AALRRLRLAQ QRQDRAHVAL VLSGEAAARR YPPAEAFDSA PPELRAGASI
DAQAFAALAE GLGYFADDRV DEPGEMAIRD AVIDIYPADA GLPARIDIAD GRITEIRSYD
PATQRTVETL DALEIGRAAE PPLGQAVPIL SHLTTGAIVL ADKADRRRAR FLQLASDAAE
RGGGAVDAIA EADWTAALAD WKIAEIGEEF EPVPRFAEKR GALAALAKFA TPRLDTRALV
LAGSRRDLRF LRGKIAKRLG IEIGEADSLA DLAALTPGAA SAIVMPVECG FVDAQRIVIA
AGDLLGSRAV LDDVPALASE RWNGGVGDIR IGDVVIHEDH GAARVAGLEP APEASGAGRE
MIALEYADGA RRLVEIDDAD RIWRYGADAD AVTLDKLDGS SWQKRRGTIQ AAIAESARQL
AKLAAARETL TAPVIEPDPA AYERFVHGFP FNETADQARA IHAVRADLAS GKPMDRLVVG
DVGYGKTEVA LRAAALAALA GYQVIVAAPT TVLVRQHLES FRRRFAASGI TVAGLSRLSS
AAEKKTVKAG LADGSIQIVV GTGAVMGKGV RYAKLGLVVI DEEQRFGAAD KARLRGSGET
HLLALSATPI PRTLQMALVG LQQISVIGTP PARRQPIRTS VDHYDDARLR TALLREKSRG
GQSFVVVPRI EDMAPLAEKL RRAAPDLALV QAHGKLPAAE IDAVMVGFAE GEGDILLATN
IIEAGLDVPR ANTMIVWRAD RFGLAQLHQL RGRVGRGNRR GQVILLTKTE DAIGERTLKR
LRTLATFDRL GAGFEISARD LDMRGAGDLL GDDQTGHMKL IGTDLYQHLL GGALREARGE
TVEHWTPELN LGEAGAFPES WIPEPDVRLA LYVRYARIED DAALDAFEEE LLDRFGPLPP
AAAALMLRAR IRIAAHALRI ERIDAGTAAI ALTPRRGFDA DAKAAGLDEK NGRLLLREPA
DDPARSERVH ALLEDLAA
//