ID A0A1G5UVI1_9FIRM Unreviewed; 1281 AA.
AC A0A1G5UVI1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN02910343_00143 {ECO:0000313|EMBL:SDA37642.1};
OS Allisonella histaminiformans.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Allisonella.
OX NCBI_TaxID=209880 {ECO:0000313|EMBL:SDA37642.1, ECO:0000313|Proteomes:UP000199689};
RN [1] {ECO:0000313|EMBL:SDA37642.1, ECO:0000313|Proteomes:UP000199689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15230 {ECO:0000313|EMBL:SDA37642.1,
RC ECO:0000313|Proteomes:UP000199689};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FMXA01000003; SDA37642.1; -; Genomic_DNA.
DR STRING; 209880.SAMN02910343_00143; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000199689; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199689}.
FT DOMAIN 4..490
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 529..817
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1281 AA; 146678 MW; 6AAEAEA7EDC65DA0 CRC64;
MSNVRWTEEQ ESAITSRDRN LLLSAAAGSG KTAVLVERII RMVCDVEHPV NITSLLVLTF
TKAAASEMRT RITDALTRVL ENAEKEGKEA LSSHVSHQLA LMGSAHISTI DSFCQTLIKQ
YFYRIPLDPR YRIESDSEVL YLMKQDVLSD VLLRWYEKKE PDFIKLSDML ASRYQDGQLR
QIIMKLDSFS QSMAFPEIWL SHLADAYELA PDTTLSDLDW TDILLQDARI QVTSWCDNYR
LLFDALQPYA SQLQKYIEPL TQEYTQLNLL AESSTWHDWQ TRIQSVSFTP RLPAIRLGNM
DNPDEIKNIK DAVSDARTKI KKAFASLQSF FSIPEKAWIS QMRETAPLIR VLARLTQDFH
DAYMQKKQEE GILEFSDTEH YALTLLVDQK ASGFTPSRAQ LFPSITALEL RKNYTEVMID
EYQDTNNVQE TITALLSSGH NRFMVGDIKQ SIYRFRLADP TIFYDKYKDY VAETGSQNLR
IDLNRNFRSD PSILYGINFI FRQIMFEDSL ELNYGKSEAL YPGRSTCTDK TYVGGTIDID
ILEKPATKDM DESEADEMQD VQRIELEGVH IAHRIKDMLT RGLTIRNKAG EIQPVSYKDI
VILMRSISTK AGYLVRTLQN AGIPAICDQS DDFLETVEVR HLWSLLQILN NPRWDIPMTA
ILRSSLVGLD EQDLAHLALT RDSMQSPVSP CLFDVLIKAE SPLPSVKQEK VAAFLKLFNK
WRSLSRRNGV APLLRTILDD TEYLPYIAAL PEGNFRAAHV EAFYQKALAW DNSRNNGLYG
FLDTLHRLSK DRKKLSASSV QTETDAVQIM TIHKSKGLEF PVVFLADAAC QFNTDDLHQS
ALLHKTEGIG FQYFDEEHKL RWPTLYWYLL KHTMQRENLS EEARLLYVAM TRARDKLIIT
GTVKDVKTTM KKWSIPLHAR TTVPNAGYHR MPLHTITSAT CYMDWIVPAA AVSRSMATFW
DIISSIPIYE DESDTPPQFA IHIISPEDLL PELISDDSHE KDDAKDIDAM LKDYLSRSGP
VPPWTENTLS WKYPHPGSIS TPAKITATAA ARMLFDQNEE EPQSVVLTEE LTEEETYLPS
GFTEEPAFLA KDRLGTHGAA YGTLMHKVMQ YLDFKTDYPS SDSLREEIHT LHERNILTDD
EEKAILSRSG FHSPVQDILA FLHGPLGKMA RTSLVRKELP FSILLPAQLF YESCEPEENI
FLQGVIDCLL EQDDKLIIID YKTDFARTEE ELIAHYAVQL NLYAYAIQRI YAMPVSHMYL
WSFRLKKAIP IPFHRRNLRT I
//
