ID A0A1G5UZV5_9BACT Unreviewed; 1102 AA.
AC A0A1G5UZV5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Tricorn protease homolog {ECO:0000256|PIRNR:PIRNR036421};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR036421};
GN ORFNames=SAMN03080617_00231 {ECO:0000313|EMBL:SDA39150.1};
OS Algoriphagus alkaliphilus.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Algoriphagus.
OX NCBI_TaxID=279824 {ECO:0000313|EMBL:SDA39150.1, ECO:0000313|Proteomes:UP000198756};
RN [1] {ECO:0000313|EMBL:SDA39150.1, ECO:0000313|Proteomes:UP000198756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22703 {ECO:0000313|EMBL:SDA39150.1,
RC ECO:0000313|Proteomes:UP000198756};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Degrades oligopeptides. {ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SIMILARITY: Belongs to the peptidase S41B family.
CC {ECO:0000256|ARBA:ARBA00008524, ECO:0000256|PIRNR:PIRNR036421}.
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DR EMBL; FMXE01000002; SDA39150.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5UZV5; -.
DR STRING; 279824.SAMN03080617_00231; -.
DR OrthoDB; 9815657at2; -.
DR Proteomes; UP000198756; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd07562; Peptidase_S41_TRI; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.750.44; -; 1.
DR Gene3D; 2.120.10.60; Tricorn protease N-terminal domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005151; Tail-specific_protease.
DR InterPro; IPR028204; Tricorn_C1.
DR InterPro; IPR029414; Tricorn_PDZ.
DR InterPro; IPR012393; Tricorn_protease.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43253; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR PANTHER; PTHR43253:SF1; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR Pfam; PF07676; PD40; 2.
DR Pfam; PF03572; Peptidase_S41; 1.
DR Pfam; PF14684; Tricorn_C1; 1.
DR Pfam; PF14685; Tricorn_PDZ; 1.
DR PIRSF; PIRSF036421; Tricorn_protease; 1.
DR SMART; SM00245; TSPc; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR036421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036421};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR036421};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|PIRNR:PIRNR036421}.
FT DOMAIN 849..1054
FT /note="Tail specific protease"
FT /evidence="ECO:0000259|SMART:SM00245"
FT ACT_SITE 745
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 971
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 1043
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT SITE 972
FT /note="Transition state stabilizer; via amide nitrogen"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-3"
SQ SEQUENCE 1102 AA; 123564 MW; A9140EC91A909332 CRC64;
MVLKKWMLTG LASFGLIAFG FSQEKPGYFM YPDIHENTVV FVAEGDLWKT SLNGGEAIRL
TTHAGEESSP KISPDGKWVA YAATYEGPTE VYLIPISGGL PRRLTYEPAA SIPTAWKSAS
EVAYVTNQYS TLPRLNTVVI NIENGSKSIV PLDMAAEGSF NASGDTYFFV RPTFHNNVTK
RYEGGTARQL WKYTSGQAEA VKLTNEYKGE DHHPIYHNGR VYFLSSRDGI QNVWSMNENG
SDLKQHTKQS SYDVREVSIH GNNLVYRSGA DLYLHELSNG QDKKLAISLT SDFDQLREYW
IDNPANYIST ISVSDDGEKV ALTARGRVFV FPAKQGRSLR LSQKDGVRYR DAVFSPDGKD
ILTFSDESGE FEIHQYSGLG LDQGKKITSD GTTLRFGLLP SPDGKKLAYY DLNNELWIQE
IASGKKVKAN ASDENLSGSM AWSPDSKWLA FGQAASNTFM QLFIFNSETG KRIPLTSDRT
NSMNPQWSPD GKWIYFMSDR NFESRIGSPW GTRQPEPFWE KQIKIYQVGL KKGLVSPFQP
KNELKPAEEK KAEGPVTVSI DEEGLIERVR EVPIPAGNYK SLVVTDKALY YHRVGPGMGI
YYGGGAPNDD NPALMMTPID EKAEQKVFAD KINSFVTSLN NKFAVLRQGN NHYVVELGTS
PVSDLSKNQL NLSGWKFSVD PREDWRQIYT DAWRMERDYF YDPNMHGVDW DAMYKKYLPL
VDRVTTRREL SDVMGELIGE LSVLHTSVGG GDLREGDDKI QFGMLGGKFS RNEKLRGYSI
DHIFKSDPDY PDEMSPLSHP DLNVSIDDVI THIDGVSVMD APDLLYLLRD KANKQVRIKV
LSSSGADKGD RIILPMTSAA ESNLRYNEWE YTRRLIAEEK SNGEIGYVHL RAMTAPDIGQ
WYRDFYPQFK KSGLVIDVRQ NRGGNIDSFI LEKLMREVFF YWKSRTGEPY WNMPYAFRGH
LVLLVDEFTA SDGEAFAEGF RRLDMGQAIG ARTWGGEVWL SGVNTLTDNG VARAPMNGVY
GVVGEKLVGG DTDQGESVEW LIEGVGFIPD IEVINMPKAT FDGKDAQLDA AIEHLKALIK
ADPRAVPQAP AYPDKSFKNG KN
//
