ID A0A1G5XYP0_9FIRM Unreviewed; 320 AA.
AC A0A1G5XYP0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=2-dehydro-3-deoxy-phosphogluconate aldolase {ECO:0000256|ARBA:ARBA00013063};
DE EC=4.1.2.14 {ECO:0000256|ARBA:ARBA00013063};
GN ORFNames=SAMN02910368_02424 {ECO:0000313|EMBL:SDA74755.1};
OS Lachnospiraceae bacterium G11.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1200747 {ECO:0000313|EMBL:SDA74755.1, ECO:0000313|Proteomes:UP000198652};
RN [1] {ECO:0000313|EMBL:SDA74755.1, ECO:0000313|Proteomes:UP000198652}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G11 {ECO:0000313|EMBL:SDA74755.1,
RC ECO:0000313|Proteomes:UP000198652};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-
CC phosphate + pyruvate; Xref=Rhea:RHEA:17089, ChEBI:CHEBI:15361,
CC ChEBI:CHEBI:57569, ChEBI:CHEBI:59776; EC=4.1.2.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000654};
CC -!- SIMILARITY: Belongs to the KHG/KDPG aldolase family.
CC {ECO:0000256|ARBA:ARBA00006906}.
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DR EMBL; FMWZ01000019; SDA74755.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5XYP0; -.
DR STRING; 1200747.SAMN02910368_02424; -.
DR OrthoDB; 9802667at2; -.
DR Proteomes; UP000198652; Unassembled WGS sequence.
DR GO; GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IEA:UniProtKB-EC.
DR CDD; cd00452; KDPG_aldolase; 1.
DR CDD; cd06587; VOC; 1.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR000887; Aldlse_KDPG_KHG.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR031337; KDPG/KHG_AS_1.
DR InterPro; IPR031338; KDPG/KHG_AS_2.
DR NCBIfam; TIGR01182; eda; 1.
DR PANTHER; PTHR30246; 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE ALDOLASE; 1.
DR PANTHER; PTHR30246:SF2; KHG_KDPG ALDOLASE; 1.
DR Pfam; PF01081; Aldolase; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR PROSITE; PS00159; ALDOLASE_KDPG_KHG_1; 1.
DR PROSITE; PS00160; ALDOLASE_KDPG_KHG_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000198652}.
SQ SEQUENCE 320 AA; 34384 MW; 6CF942D79CBF9E40 CRC64;
MNKVLEEISK IGIVPVIALD EVKDAKPLAK ALIDGGLPCA EVTFRTAAAE ESIRVIAEEF
PEMLVGAGTV LTTEQVDKAV AAGAKFIVSP GLNPEVVKYC VDKNIPVCPG CSNPSDIEQA
ISLGLDVVKF FPAEAAGGLA MIKAMSAPYT NMKFMPTGGI NAKNLNEYLG FKKIIACGGS
WMVKPDMIKA GEFDKITALT KEAVELMLGF ELKHVGINSK DEKEAEKTTS AFCDIFGFAK
DERSASYFAG TGLEIMKMQG RGTMGHIAIA TNSVERAVYH LSKKGCQFDM NSATYDNDGK
MKFIYIKDEL GGFGVHLVNK
//
