ID A0A1G5ZZS4_EUBOX Unreviewed; 690 AA.
AC A0A1G5ZZS4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=C-di-AMP phosphodiesterase, consists of a GGDEF-like and DHH domains {ECO:0000313|EMBL:SDB01667.1};
GN ORFNames=SAMN02910417_00030 {ECO:0000313|EMBL:SDB01667.1};
OS Eubacterium oxidoreducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1732 {ECO:0000313|EMBL:SDB01667.1, ECO:0000313|Proteomes:UP000199228};
RN [1] {ECO:0000313|EMBL:SDB01667.1, ECO:0000313|Proteomes:UP000199228}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3217 {ECO:0000313|EMBL:SDB01667.1,
RC ECO:0000313|Proteomes:UP000199228};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FMXR01000004; SDB01667.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5ZZS4; -.
DR STRING; 1732.SAMN02910417_00030; -.
DR OrthoDB; 9759476at2; -.
DR Proteomes; UP000199228; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.10.310.30; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR003156; DHHA1_dom.
DR InterPro; IPR014528; GdpP/PdeA.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR PANTHER; PTHR47618; BIFUNCTIONAL OLIGORIBONUCLEASE AND PAP PHOSPHATASE NRNA; 1.
DR PANTHER; PTHR47618:SF2; CYCLIC-DI-AMP PHOSPHODIESTERASE GDPP; 1.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02272; DHHA1; 1.
DR PIRSF; PIRSF026583; YybT; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199228};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 207..335
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 690 AA; 78020 MW; 9248E972BCCF7F98 CRC64;
MGKQNELTAS LRAHVRWPLQ VVIIFVVADI ISYFLSPYAG AVGSIAIGIY LVFTIPAYIR
SKKQIQELLV EFATHYGTMQ KRLLNEFEVP YALLDENGKI LWMNKKFQET SGRARTYHKS
INAIIGTITK EWLQRENVYT MEQHINLGDR DYRASIQKVF MQEVLPQAEG ESQGSKDIKQ
QRKDYIFTLY LFDETRLNEY IRKNEEQRLV SALVYIDNYD EVLDKTADMK SSMVSAIVTR
QISDYFSKYD AIVRRTERDK FYVVFKYANL QSLIEDKFSL IESVKKIKAG NEMSLTLSIG
IGVNKTTYVQ NYEYARMAID LALGRGGDQV VIKNGDQISY FGGKTQQIEV NTRVKARVKA
HALREIIESH EHILIMGHKI GDVDSFGAAI GLYVGAKALG RTPKIVLNEV TSSLKPFKEF
FTEENGYEEN MFINGETAID FCDAKTVVIV VDTNRPAHTE CEEILKKSKT VVVFDHHRQG
NERIENAVLS YIESYASSTC EMVAEILQYL TDGIKLNHQE ADSIYAGILI DTNNFMTKTG
VRTFEAAAYL RRSGAEVTRV RKLLRNDMND YKARAEAVRH AQVYKGVFAI SICPADELES
PTVVGAQAAN ELLNIIGIKA SFVLTEYNDK IYISSRSIDE INVQLIMERL GGGGHLSVAG
AQLEHATLED AEEALKMTLN ELIEEGQITL
//
