ID A0A1G6ALB1_EUBOX Unreviewed; 881 AA.
AC A0A1G6ALB1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN02910417_00668 {ECO:0000313|EMBL:SDB09178.1};
OS Eubacterium oxidoreducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1732 {ECO:0000313|EMBL:SDB09178.1, ECO:0000313|Proteomes:UP000199228};
RN [1] {ECO:0000313|EMBL:SDB09178.1, ECO:0000313|Proteomes:UP000199228}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3217 {ECO:0000313|EMBL:SDB09178.1,
RC ECO:0000313|Proteomes:UP000199228};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FMXR01000006; SDB09178.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6ALB1; -.
DR STRING; 1732.SAMN02910417_00668; -.
DR Proteomes; UP000199228; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000199228}.
FT DOMAIN 694..710
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 881 AA; 99657 MW; 1A2CA6970674CF09 CRC64;
MAELTPMMAQ YMKTKEEYRD CILFYRLGDF YEMFFDDAIT VSKELELTLT GKACGLEERA
PMCGVPYHAA ESYLNRLVSK GYKVAICEQV EDPKLSKGLV KREVIRIVTP GTNLDASMLD
DGRNNFLMCI VYTTNSIGLS IADISTGEFY TTEVDTFRGI MDEIYKYAPS EIICNDAFTV
SGFDITQIKE RLQICISPLD DWYFNDDTAT QTVLEHFRVK QLEGLGLSDF PVGTVASGAL
LTYLEQTQKN DLGQMTSIHP YRIGKFMIID SFTRRNLELI ETMREKQKRG SLFWVLDKTK
TAMGARMLRS FIEQPLLNVE AIKQRQDAIE ELMKDMISRE EIREYLTPVY DLERLISRVT
YQNANPRDLI SFKTSLSMLP AIKTILSEFH SDLLRNLNEQ LDPLEDIHAL IERSIVDEPP
LLVREGGIIK EGYHTEVDRL KTAKNEGTSW LAGLEEKERE KTGIKNLKIK FNKVFGYYLE
VTNSYKDLVP EYYMRKQTLT NAERYITPEL KEMEDTILGA QDRLVGLEYD LFCEIRSSIA
KEVVRIQQTA KAIALLDVLC SLAQVAEQNN YCRPVVNEKG KIEITKGRHP VVEKMISNDL
FISNDTYLDH NKKRVAIITG PNMAGKSTYM RQCALIVLMA QIGSFVPAEK AKIGIVDRIF
TRVGASDDLS SGQSTFMVEM NEVANILRNA TSDSLLILDE IGRGTSTFDG LSIAWAVVEH
ISNPKLLGAK TLFATHYHEL TELEGKLDNV TNYCVAVKEN GDDIVFLRKI VPGGADKSYG
IQVAKLAGVP DGVIERAKQI AGELATQDIT ERVKAIAEEN GKKETKKNVP DAMDMAQISL
FDVMNDDDIL EEIKELEIGN MTPVDALNKL YEIQCKINNR W
//
