ID A0A1G6CUK8_9GAMM Unreviewed; 1125 AA.
AC A0A1G6CUK8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN02927930_01385 {ECO:0000313|EMBL:SDB36563.1};
OS Pseudidiomarina indica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Idiomarinaceae; Pseudidiomarina.
OX NCBI_TaxID=1159017 {ECO:0000313|EMBL:SDB36563.1, ECO:0000313|Proteomes:UP000199626};
RN [1] {ECO:0000313|Proteomes:UP000199626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10824 {ECO:0000313|Proteomes:UP000199626};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000256|ARBA:ARBA00006434}.
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DR EMBL; FMXN01000007; SDB36563.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6CUK8; -.
DR STRING; 1159017.SAMN02927930_01385; -.
DR OrthoDB; 9764438at2; -.
DR Proteomes; UP000199626; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.20.1730.10; Sodium/glucose cotransporter; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF9; HISTIDINE KINASE; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF12860; PAS_7; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000199626};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 775..985
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1009..1123
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 1056
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1125 AA; 124585 MW; D1EA4B7808EF3331 CRC64;
MLSTGLTILL AMAYIAVLYS IAYRGERRSS NQHKPYRYAL AQGIHCTTWA FYGTMTQSAF
YGWSVAPTYI GAMLVFLFAH RLQMRLLHVC KQQNLTSISD VISQRYGKSP TLAIAVAIIA
LIGIIPYIAL QLRAVSSSFG AVTGLTATPL PWFIDVVVLV AIAMIGFAIL FGTRRMSLAE
QHAGLMDAVA FESVVKLAAF MGVGFYVSYV LFDNVTDIFV QASQQPAITA VLAGQPHGGF
VYMTHIILGA ISMFCLPRQF HVSYIENNDP EELKTARWAF PLYLFAINLF ILPLALAGLL
LVPEAMHSDT LMISLLLTAD DPGITAIAFI GGLASATSMV IIATLALSIM ISNDVVMPLW
LKSTKRKFRN EIFTPQKILS IRRTTIALII VFALGFHKLT EANLPLVNAG LLSLALLAQL
APALLGGIIW SRGNRVGASV GITMGTLLWF GLLFLPSLQR DPGLSDIALS SGVLVSLSVN
VLCYFLFSII TKASPIETQL RALYTDPQGD HTEFYPHHAI SWGRLRQLLT RFFNYAELER
LSERLNHNLA VAPADELVPG AILVKIEREL SAVIGTAASR ILLDTVTQQP AVPIAHVVTW
ATEASQLYKF NRELLQASVE NIPQGISVID QELRLVAWNQ RYVELFSYPP NFLQAGMPVA
ELLRFNAQRG LIATAAASDI DEEVEKRLNY LRHGSAYRYQ RQQGEFVIEL QGNPMPGGGF
VTTYTDITEL VAAQRALEQV NIELEQRVAD RTAQLLAAKQ AEERAHQSKS KFFAAVSHDL
MQPFNAATLF CDLLAQRADP SSQQLVRQVQ QSLKNAEELL TMLLEMTRLE AGNLPVNKQH
TALHDVIGPL VENQRIIAAD KGVEVHYVPT RATVYTDRKM LSRVVQNLLS NAIRYTDHGK
VLIGTKRCGT QLQIRVYDTG RGIPADQRNK IFTEFHQVHQ QGGNPGLGLG LAIVDRMCRL
LELPLTLTSQ VGQGTLFAIT LPEVHWPPQT TSSPELQTSH DEEFLHGQVV WILDNDPQVL
QAMEQLLIAW GARVHTALNR EQLPWHQPPP QLLIFDYHLD EQDTGVAVLT KVREHYQLPE
LPAIINSADP DETVREEVIA TAALFTPKPI KTAALKRLIK RLVND
//
