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Database: UniProt
Entry: A0A1G6CVX4_9FIRM
LinkDB: A0A1G6CVX4_9FIRM
Original site: A0A1G6CVX4_9FIRM 
ID   A0A1G6CVX4_9FIRM        Unreviewed;       167 AA.
AC   A0A1G6CVX4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   ORFNames=SAMN02910298_01787 {ECO:0000313|EMBL:SDB37067.1};
OS   Pseudobutyrivibrio sp. YE44.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Pseudobutyrivibrio.
OX   NCBI_TaxID=1520802 {ECO:0000313|EMBL:SDB37067.1, ECO:0000313|Proteomes:UP000198713};
RN   [1] {ECO:0000313|Proteomes:UP000198713}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YE44 {ECO:0000313|Proteomes:UP000198713};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting sites
CC       in DNA have the property of trapping a certain fraction of elongating
CC       RNA polymerases that pass through, resulting in locked ternary
CC       complexes. Cleavage of the nascent transcript by cleavage factors such
CC       as GreA or GreB allows the resumption of elongation from the new
CC       3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC       {ECO:0000256|ARBA:ARBA00024916, ECO:0000256|HAMAP-Rule:MF_00105}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00105}.
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DR   EMBL; FMXT01000005; SDB37067.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6CVX4; -.
DR   STRING; 1520802.SAMN02910298_01787; -.
DR   OrthoDB; 9808774at2; -.
DR   Proteomes; UP000198713; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.50.30; Transcription elongation factor, GreA/GreB, C-terminal domain; 1.
DR   Gene3D; 1.10.287.180; Transcription elongation factor, GreA/GreB, N-terminal domain; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   PANTHER; PTHR30437; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   PANTHER; PTHR30437:SF4; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF54534; FKBP-like; 1.
DR   SUPFAM; SSF46557; GreA transcript cleavage protein, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00105}; Elongation factor {ECO:0000313|EMBL:SDB37067.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:SDB37067.1};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00105};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00105}.
FT   DOMAIN          5..73
FT                   /note="Transcription elongation factor GreA/GreB N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03449"
FT   DOMAIN          80..151
FT                   /note="Transcription elongation factor GreA/GreB C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01272"
SQ   SEQUENCE   167 AA;  19148 MW;  549B7FD5E2738AEB CRC64;
     MGERLTQGDI DKIQAEIDER KLVIRPKLLE EVKETRAQGD LSENFEYHEA KRAKNMNDSR
     IRYLEKMLKF AEVVDDSSAD DEVGINNTVT IYIPEDDCEE TYKLVTSIRG NSLKGLISIE
     SPLGSAIRGK HVGDKVMVKV NDDYSYEVEI RLIDKSTTDE DDKIKRY
//
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