ID   A0A1G6GE07_9ACTN        Unreviewed;       328 AA.
AC   A0A1G6GE07;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Thiamine monophosphate synthase/TENI {ECO:0000313|EMBL:SDB80139.1};
GN   ORFNames=GA0111570_101414 {ECO:0000313|EMBL:SDB80139.1};
OS   Raineyella antarctica.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Raineyella.
OX   NCBI_TaxID=1577474 {ECO:0000313|EMBL:SDB80139.1, ECO:0000313|Proteomes:UP000199086};
RN   [1] {ECO:0000313|EMBL:SDB80139.1, ECO:0000313|Proteomes:UP000199086}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LZ-22 {ECO:0000313|EMBL:SDB80139.1,
RC   ECO:0000313|Proteomes:UP000199086};
RA   Olsen C.W., Carey S., Hinshaw L., Karasin A.I.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole
CC       monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine
CC       pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
CC       {ECO:0000256|ARBA:ARBA00003814}.
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004948}.
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DR   EMBL; FMYF01000001; SDB80139.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6GE07; -.
DR   STRING; 1577474.GA0111570_101414; -.
DR   Proteomes; UP000199086; Unassembled WGS sequence.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR036206; ThiamineP_synth_sf.
DR   InterPro; IPR022998; ThiamineP_synth_TenI.
DR   Pfam; PF02581; TMP-TENI; 1.
DR   SUPFAM; SSF51391; Thiamin phosphate synthase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199086};
KW   Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977}.
FT   DOMAIN          17..129
FT                   /note="Thiamine phosphate synthase/TenI"
FT                   /evidence="ECO:0000259|Pfam:PF02581"
FT   REGION          245..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   328 AA;  34683 MW;  F1565F32E9EB6351 CRC64;
     MTILQPVCQR LSAARLYAVV VPAPFTPPDA LVRRVEDLVA SGVDILQLDL DGWEHDDAVA
     VLNRCTPVVV PTGRLLVVGH APDVAVDLGA DALLLGPAQA LPGDVPGRLG PQAAIGREVG
     DEEHLGELLE GRDVSFVVLV GGRAAQVAER AHQLAPLAGP DACADPAAGT RPWFVDIGSH
     WPDPVAVPER ACRIRFEVFV PADSPITEPS PQLRVDIADL ASRVAARWEA DEALAAERDR
     LAAENSAAST SFRARTDGGR SGAADPYDTD AVRNYRSSSE RAGGERLDWP RPIREFFARA
     FHRAPAGRGP ADGGQDGSDA ATHGGVRE
//