ID A0A1G6GEP5_9ACTN Unreviewed; 286 AA.
AC A0A1G6GEP5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=2,5-diketo-D-gluconate reductase A {ECO:0000313|EMBL:SDB80434.1};
GN ORFNames=GA0111570_102224 {ECO:0000313|EMBL:SDB80434.1};
OS Raineyella antarctica.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Raineyella.
OX NCBI_TaxID=1577474 {ECO:0000313|EMBL:SDB80434.1, ECO:0000313|Proteomes:UP000199086};
RN [1] {ECO:0000313|EMBL:SDB80434.1, ECO:0000313|Proteomes:UP000199086}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LZ-22 {ECO:0000313|EMBL:SDB80434.1,
RC ECO:0000313|Proteomes:UP000199086};
RA Olsen C.W., Carey S., Hinshaw L., Karasin A.I.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FMYF01000002; SDB80434.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6GEP5; -.
DR STRING; 1577474.GA0111570_102224; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000199086; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19133; AKR_AKR5F1; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000199086}.
FT DOMAIN 21..261
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 48
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 111
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 73
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 286 AA; 32064 MW; 848322F8427616A9 CRC64;
MQNVTLNNGV KMPILGFGVY QVPPEATEQA VSDALAVGYR HLDTAAAYGN EIAVGRAIAS
SGIPREELFV TTKLWVQDSG LRGAGEDNAR RACETSMHRL GLEYLDLYLI HQPYGDYYSS
WRAMQELHRD GLVEAIGVSN FMPDRLVDLI TNNEIVPAVN QIETHPFYQR ADYQRLMDKH
GVRIQSWGPF AEGRNNLFGN EVLSGIGTAH EKSVAQVVLR WLIQRGVVVI PKSVHPERMA
ENFDVFDFEL SEDEMARIAT LDQGVSQFFD HRDPGMTKRL GSSRVD
//
