ID A0A1G6IHJ5_9BACT Unreviewed; 825 AA.
AC A0A1G6IHJ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=SAMN04488588_0358 {ECO:0000313|EMBL:SDC05206.1};
OS Geotoga petraea.
OC Bacteria; Thermotogota; Thermotogae; Petrotogales; Petrotogaceae; Geotoga.
OX NCBI_TaxID=28234 {ECO:0000313|EMBL:SDC05206.1, ECO:0000313|Proteomes:UP000199322};
RN [1] {ECO:0000313|EMBL:SDC05206.1, ECO:0000313|Proteomes:UP000199322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WG14 {ECO:0000313|EMBL:SDC05206.1,
RC ECO:0000313|Proteomes:UP000199322};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; FMYV01000001; SDC05206.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6IHJ5; -.
DR STRING; 28234.SAMN04488588_0358; -.
DR Proteomes; UP000199322; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000199322};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 17..473
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 408..486
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 825 AA; 92446 MW; 2C4CCA884A4CB330 CRC64;
MSEENNDKII HGGHEDQRFV DELRTSYLLY SLSVIVSRAI PDVRDGLKPV QRRILYSMNE
LGLKHTSSYK KSARIVGEVM GKYHPHGDSS IYDALVRMAQ PFSMRYMLVN GQGNFGSIDK
DPAAAMRYTE ARMFEESEFM LKDIDKNTVD YIDNFDGSLK EPVVLPTRMP ALLMNGVSGI
AVGMATSIPP HNLTELVDGI KHFIDHPEAE AEELMEFIKG PDFPTGGIIV DGENIQDMYE
TGRGKVTIRS KYEIVEDNNG SSIIVSEIPY AVSKVDIIDQ IVAYAVRKKE NKKDSGIKDV
RDETDKRGMR LVIELKKNAN IKRLINDLLK HTSLQSSFSV QMNVINKGKP SLMNLKGLIQ
AFLEHRVDVI TKRTEYDLQK AKKRAHIVEG LIKAVDGIDT VIEIIRNSDG VEDALANLQA
TIDVSEEQAK AISEMRLISL SKLEINKLTS ELKQLTEKIS YCNTILQNQN VLNDIIKEEL
DEIKNKFGDD RRTKILKYKS DLKKYEELIE DEDIIIVLTK WGYIKAIPSS QYKAQGRGGK
GVKGLKISDN DSVLEILYTN RLSKLMIITS AGKAYQLPAY EIDMSQKTTK GKHIANYLDL
TEDESIKAIT TVSLKGDYEK DIMIFTKKGK VKKTSLSEFA NARTKGIRAI NLRDDDMVVD
ALVMNSLDDD VLLVTKNGMS LRFSSKDVRN MGRGASGVNS IKLRKNDEVV NAVLVEHDKK
LMIITSKGYG KRTKFSSYRR QNRGGIGIKT VRDITKIGTI VSALSINDGS DILIFTKNGK
AIRTTIDNIS VLNRVTQGVI TVRLSPDDEV VGMIVVKVDE DDENI
//
