ID   A0A1G6ISP3_9PSEU        Unreviewed;       251 AA.
AC   A0A1G6ISP3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
GN   ORFNames=SAMN05216174_10187 {ECO:0000313|EMBL:SDC09592.1};
OS   Actinokineospora iranica.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Actinokineospora.
OX   NCBI_TaxID=1271860 {ECO:0000313|EMBL:SDC09592.1, ECO:0000313|Proteomes:UP000199501};
RN   [1] {ECO:0000313|Proteomes:UP000199501}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBRC-M 10403 {ECO:0000313|Proteomes:UP000199501};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC         Evidence={ECO:0000256|RuleBase:RU000544};
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
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DR   EMBL; FMZZ01000001; SDC09592.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6ISP3; -.
DR   STRING; 1271860.SAMN05216174_10187; -.
DR   OrthoDB; 9781579at2; -.
DR   Proteomes; UP000199501; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR   PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR   Pfam; PF00265; TK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000544};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199501};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
SQ   SEQUENCE   251 AA;  27479 MW;  98017E04A43396D4 CRC64;
     MESNTEGADP TDALSAVPAA GSRRAVPVVG HLRFYYGPMD CGKSTLALQV DHNQARQGRK
     GLLLVHRDRS GLPQITSRIG ITRQAVEVHA GVDPRDLVRA RWASGSRVDY LIVDEAQFLV
     PEQVEQLAVL ADDSQVDVYC FGIATDFRGR LFPGARRLFE LADELLPVQV DVLCWCGLPA
     RFNARVQNGR ITHEGDTVVV ADTETTHVDT NGDHTDTSTS TTVRYQVLCR RHFRLGDLGA
     DAGVQGQLTF A
//