ID A0A1G6IZT1_9BURK Unreviewed; 319 AA.
AC A0A1G6IZT1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Metallo-beta-lactamase type 2 {ECO:0000256|ARBA:ARBA00017223};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE AltName: Full=B2 metallo-beta-lactamase {ECO:0000256|ARBA:ARBA00030107};
DE AltName: Full=Metallo-beta-lactamase type II {ECO:0000256|ARBA:ARBA00033087};
GN ORFNames=SAMN05421548_104101 {ECO:0000313|EMBL:SDC12072.1};
OS Paraburkholderia lycopersici.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=416944 {ECO:0000313|EMBL:SDC12072.1, ECO:0000313|Proteomes:UP000198908};
RN [1] {ECO:0000313|Proteomes:UP000198908}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TNe-862 {ECO:0000313|Proteomes:UP000198908};
RA Varghese N., Submissions S.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Class-B
CC beta-lactamase family. {ECO:0000256|ARBA:ARBA00005250}.
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DR EMBL; FMYQ01000004; SDC12072.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6IZT1; -.
DR STRING; 416944.SAMN05421548_104101; -.
DR OrthoDB; 5290005at2; -.
DR Proteomes; UP000198908; Unassembled WGS sequence.
DR CDD; cd16282; metallo-hydrolase-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR42951:SF20; BETA LACTAMASE; 1.
DR PANTHER; PTHR42951; METALLO-BETA-LACTAMASE DOMAIN-CONTAINING; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 33..222
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 319 AA; 35114 MW; A297475FB8E6B29E CRC64;
MAKAFASQAD LEEKKVTFTQ LSENAYAYTT EGDPNSGVIV GDDGVLIVDT TATPAMAQDL
IAKIRGITDK PIKYVVLSHY HAVRVLGASA YFKEGAQQII ASRGTYEMIV ERGEADMKSE
IERFPRLFAG VETVPGLTWP TLVFDKEITL FLGKLEVKIA HLGSGHTKGD TVVWLPSQKV
LFSGDLVEYD AACYCGDAQL AEWPATLEAL RALGPEKLVP GRGPALLDPA EVNKGLDYTK
DFVMTLLAQG RAAVEQKLDL KGAMSLTRRA MDPKFGHVFI YEHCLPFDVT RAYDEASGIT
HPRIWTAQRD KEMWDALQD
//
