ID A0A1G6KHN6_9PSEU Unreviewed; 613 AA.
AC A0A1G6KHN6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Cell division protein FtsI (Penicillin-binding protein 3) {ECO:0000313|EMBL:SDC29816.1};
GN ORFNames=SAMN05216174_101888 {ECO:0000313|EMBL:SDC29816.1};
OS Actinokineospora iranica.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=1271860 {ECO:0000313|EMBL:SDC29816.1, ECO:0000313|Proteomes:UP000199501};
RN [1] {ECO:0000313|Proteomes:UP000199501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBRC-M 10403 {ECO:0000313|Proteomes:UP000199501};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FMZZ01000001; SDC29816.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6KHN6; -.
DR STRING; 1271860.SAMN05216174_101888; -.
DR Proteomes; UP000199501; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:SDC29816.1};
KW Cell division {ECO:0000313|EMBL:SDC29816.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199501};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..226
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 277..588
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 474..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 66334 MW; F79DD710D8166A06 CRC64;
MTKRAAGTDH RVRVVVVRFL LIASLVAAGL KLVQVQGFEA EALASRAERQ RVQKIPIPAT
RGSILDRNGV ELAFSVEARA LAFQPNLQRK QIAEFNRKHP DKQVSFDEET AAIARRMREL
LGPQLSEEDL LAKLRSDDAF VYLTTTAEPA AARRLKEEFP QLNVEYRAVR EYPGGTLAAN
VVGFANWRME DKDHQKHNLH GLVGLEMLRD NDLSGTPGSQ MVETEEGADV IIPGTERDLQ
PAVDGKDIEL TIDADLQFFV QQKAAEYAQR SGAKSASVVV MDAKTGEVYA LANDKTFDPS
TRGGRDPNLM SDPAVTTPFE PGSVNKVVTA MAALEYGVTT PDAVHAVPGS IKVADRVVGD
AWDHGTLNMT TTGVFAKSSN VGTLMIANQV RPERFADMLG KLGIGKRTGI GLPGESPGKV
LPQSQWSGST YGNLPIGQGL SMTVLQMAGM YQTLANDGVR VPPRIVKAKI APDGTRLDEP
RPEPVRVVSP ETARKTRDML RAVTQKAPNQ NSGTAPAAAL TGYQISGKTG TAQQFDQAAG
RYSNSKYWIT FAGILPADNP RFVIGMVYDT PAYSTPDGHS AAPFFHDVAS FIAQRYNLPL
SKEPTPVVPL VVP
//
