ID A0A1G6L0Z6_9BURK Unreviewed; 384 AA.
AC A0A1G6L0Z6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SAMN05192589_10236 {ECO:0000313|EMBL:SDC36853.1};
OS Paracidovorax valerianellae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Paracidovorax.
OX NCBI_TaxID=187868 {ECO:0000313|EMBL:SDC36853.1, ECO:0000313|Proteomes:UP000198781};
RN [1] {ECO:0000313|EMBL:SDC36853.1, ECO:0000313|Proteomes:UP000198781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16619 {ECO:0000313|EMBL:SDC36853.1,
RC ECO:0000313|Proteomes:UP000198781};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; FMZC01000002; SDC36853.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6L0Z6; -.
DR STRING; 187868.SAMN05192589_10236; -.
DR Proteomes; UP000198781; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDC36853.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198781};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 48..95
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 107..322
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 43399 MW; 9868F175D7965DCB CRC64;
MPRTATATAP STANAPVPRP PPTRLPGGLR YVNPDMPGLT RERQGDVFRY RQPDGKWLTD
PDEISRIQKL AIPPAYTDVW ICPLANGHLQ ATGLDARGRR QYRYHADWRL QRDEAKFERM
QAFGRALPRI RARVARDLRA TPGRALSRER VLATLVRLLD TTFMRVGNEE YASANRSYGL
TTLRNRHADL RGNRLRLRFR GKSGVQQEAT LDDPRVARVV RRCQQLPGQE LFQYEDEDGT
LHAVDSGDVN DYLREITGTE EGEHFTAKDF RTWHGTVQAL ELTRLACSQQ PGTPAVTAKH
ILAEVARQLG NTPAVCKKSY VHPSVLDLGS RLTSDAGPDM QVLWDRIGGT NTPRALQAAE
RRLLAFLRHK DRPTRAKRAR KTTH
//
