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Database: UniProt
Entry: A0A1G6LN35_9BURK
LinkDB: A0A1G6LN35_9BURK
Original site: A0A1G6LN35_9BURK 
ID   A0A1G6LN35_9BURK        Unreviewed;       808 AA.
AC   A0A1G6LN35;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SDC44126.1};
GN   ORFNames=SAMN05216345_102313 {ECO:0000313|EMBL:SDC44126.1};
OS   Cupriavidus sp. YR651.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=1855315 {ECO:0000313|EMBL:SDC44126.1, ECO:0000313|Proteomes:UP000198719};
RN   [1] {ECO:0000313|EMBL:SDC44126.1, ECO:0000313|Proteomes:UP000198719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YR651 {ECO:0000313|EMBL:SDC44126.1,
RC   ECO:0000313|Proteomes:UP000198719};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FMYZ01000002; SDC44126.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000198719; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000198719};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN        8    191       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      194    293       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   808 AA;  86185 MW;  6B627683D42DF882 CRC64;
     MSNFIVKKVA VLGAGVMGAQ IAAHLVNARV PVVLFDLPAK EGPKNGIAQR AIENLKKLSP
     APLGIKDEAG LIRPANYEDD IALLKECDVV IEAIAERMDW KHDLYKKVAP HLAPNAIFAT
     NTSGLSITAL SDGFDADLKA RFCGVHFFNP PRYMHLVELI PTATTQPEIL DRLEAFLTTT
     LGKGVVRAKD TPNFIANRVG IFSILAVFAE AEKFGIPFDV VDDLTGSKLG RAKSATFRTA
     DVVGLDTMAH VIKTMQDNLT NDPFAPVYKT PAVLKGLVDA GALGQKTGAG FYKKEGKAIK
     VLDAKTGQYV ESGKKADEIV VRMLKKDPAE RIKLLRESTN PQAQFLWGVF RDVFHYIAVY
     LEQIAGSAAD IDLAIRWGFG WNSGPFEDWQ AAGWKQVAEW VKEDIDAGRA LSNAPLPAWV
     LDGAVAANQG VHSAQGSWSP AASAFVKRAA LPVYERQVFR AALKGTDAAD PRKAGKTVEE
     NDGARIWTSE GADDVLIISF KSKMNTVGPD VLDTIVRAVE LAEADYKGLV VWQPTSLQLG
     APGGPFSAGA NLEAAMPAFM MGGAKGIEPF VKKFQDTMMR VKYAAVPVVP AVSGIALGGG
     CELMLQSAKR VVALESYVGL VEVGVGLVPA GGGLKEAAIA AARAAQAAGS TNYLSFLTNR
     FQAAAMAKVS TSALDAQKMG YVQPTDTIVY NVHELLYVAQ SEVRALANAG YRAPVPGALV
     PVAGRSGIAT IKASLVNMRD GNFISAHDFL IASRIAEAVC GGDVEAGSLV SEEWLLALER
     KAFIELLGTG KTQERIMGML QTGKPVRN
//
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