ID A0A1G6LRX5_9BURK Unreviewed; 560 AA.
AC A0A1G6LRX5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Chloride channel protein, CIC family {ECO:0000313|EMBL:SDC45941.1};
GN ORFNames=SAMN05216345_102384 {ECO:0000313|EMBL:SDC45941.1};
OS Cupriavidus sp. YR651.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1855315 {ECO:0000313|EMBL:SDC45941.1, ECO:0000313|Proteomes:UP000198719};
RN [1] {ECO:0000313|Proteomes:UP000198719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR651 {ECO:0000313|Proteomes:UP000198719};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FMYZ01000002; SDC45941.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6LRX5; -.
DR STRING; 1855315.SAMN05216345_102384; -.
DR OrthoDB; 9767361at2; -.
DR Proteomes; UP000198719; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd02205; CBS_pair_SF; 1.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198719};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 504..560
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 560 AA; 57824 MW; 33D2C5E8E34D0270 CRC64;
MRLRFLEDQE VTLFAAIPVG ILAGIVTTLF KEALEASGLV MFGSHTDVVM VFAGLALFWR
VVIPALGGAL AGALLMLASR LAAAQPGPTD YMEAVSRGTG RLPLAITLLR SLSSFCSIVS
GSSVGKEGAM IQLAALCGSL FPSSRADNAA GDSNMRRMLT ACGAAAGLAT VYHTPLSAAV
FVAEVVFGAL AVQRLMPLFL ASVAGAMVSQ WHGGLQPLYP GLHIAPDLRP QILLAAAALG
VLAGAAGALF MRAATLARNA FTHVPGGPIA RLAIGGALVG ALAMAVPEVV GNGFFTIQTI
LHGDPLSVPV WGVLVAKLVA TVASMGSGAV GGVFTPSLFV GAALGQMLAI MIPGGTVSPV
LPLVGMSAFL AATSQAPLMS VLMVFEMTLA PALLLPSMIG AVAAYYTASR CQTMSLYSVV
VERAQASAAV ERARALRLAG LCDPTDTVID PDATVAATAD KFAETGTRYL YLVTPAGTLL
GAISIHAIQR AQRERPDASL LALAERDFPS LTPDSRLRDA LALFSEHGIN RIPLIRDTVS
RELLGTVSKQ RVLQEASCLF
//
