ID   A0A1G6N0Z8_9BACI        Unreviewed;      1000 AA.
AC   A0A1G6N0Z8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=type I site-specific deoxyribonuclease {ECO:0000256|ARBA:ARBA00012654};
DE            EC=3.1.21.3 {ECO:0000256|ARBA:ARBA00012654};
GN   ORFNames=SAMN05421734_11320 {ECO:0000313|EMBL:SDC60896.1};
OS   Pelagirhabdus alkalitolerans.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Pelagirhabdus.
OX   NCBI_TaxID=1612202 {ECO:0000313|EMBL:SDC60896.1, ECO:0000313|Proteomes:UP000242949};
RN   [1] {ECO:0000313|Proteomes:UP000242949}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S5 {ECO:0000313|Proteomes:UP000242949};
RA   Varghese N., Submissions S.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of DNA to give random double-stranded
CC         fragments with terminal 5'-phosphates, ATP is simultaneously
CC         hydrolyzed.; EC=3.1.21.3; Evidence={ECO:0000256|ARBA:ARBA00000851};
CC   -!- SIMILARITY: Belongs to the HsdR family.
CC       {ECO:0000256|ARBA:ARBA00008598}.
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DR   EMBL; FMYI01000013; SDC60896.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6N0Z8; -.
DR   STRING; 1612202.SAMN05421734_11320; -.
DR   OrthoDB; 9758243at2; -.
DR   Proteomes; UP000242949; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009035; F:type I site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd22332; HsdR_N; 1.
DR   Gene3D; 3.90.1570.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR007409; Restrct_endonuc_type1_HsdR_N.
DR   InterPro; IPR040980; SWI2_SNF2.
DR   PANTHER; PTHR42927; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR42927:SF1; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF04313; HSDR_N; 1.
DR   Pfam; PF18766; SWI2_SNF2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242949};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT   DOMAIN          296..500
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   REGION          874..895
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1000 AA;  115931 MW;  BCEB4F7D2AA13FED CRC64;
     MSIDYSERGF EENIEQHLIE SGYRQRTLEG KALETFQKWA IDQDILFEFW ESTQPQSLER
     LKKAYKDQYE FKIMSRLDKE LKKRGIIDCL RHGIKDYGVT LNLAYNKPVT DMNRTLVENY
     EKNIFTVSRQ VYYSQKHRSS VDMMLSLNGL PIVVKELKNQ LTSQTVEHSM KQFKKDRDPR
     EMLFQFKSRT VVYFAVDTDE VHMTTRLNRD KTFFLPFNRG NNGGKGNPPV EDDYRSSYLW
     KEILQKDSLL DILFRFVYVQ QEDMKDSNGE VIDTKEVVIF PRFHQLDAVR KIEQDVSEHR
     SGKNYLIQHS AGSGKTNSIS WLSHRLAKLH DHQDEPIFDS IIVITDRRVL DKQLQDAVYQ
     LEHKAGMVAK IDRDSNQLAG AIRNKTKIII TTLQKFPFIL EEVGSFNRGS YAVIIDEAHS
     SQGGKSSGAM TSILSDKTLE EAYEESMREE SETTDAEERM IEHIAKTGDQ DNISFFAFTA
     TPKPKTIDRF GTEQEDGQKA PFHLYSMRQA IEEGFIHDVL NNYVTYETFY KVEKMIHDDP
     EVAKSKASKQ IARYVSLHPY NIAQKAEIMV EHFRNVTRHK IDKRAKAMVV TSSRKHAVRY
     KFAFDHYIKS KGYADMRTLV AFSGTVEDQG ESYTEPDING ISEKELPEQF HSDDYQVLIV
     AEKYQTGFDE PLLHTMYVDK PLDGIKAVQT LSRLNRTCKG KDDTFILDFA NDPETIQQAF
     QAYYEVTTLD AQTDPNILYD LQHELDAMQV YTDDELDKVA NLEYSGKSMK DSRMQVKLNA
     SLDPAVERFK HELTEEEQEA FKSAATKFVR TYAFVLQIGP FSDLDLHKRF IFLTYLLKKL
     PKKPEDPIYI SDDVALEYYR NEKAFEGSIS LTEQGGEALS PAEHGTAGST EEDKERLSSI
     IERINDRFGT DFSDTDKLSR DQIALDIKEQ EAMAEKAKNN SIDNFKYSAE KSFLDSVISR
     MKMNEEFHMR ILEDPEFKEF LMNDILTEVY HDLRREEGAY
//