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Database: UniProt
Entry: A0A1G6PRV7_9ACTN
LinkDB: A0A1G6PRV7_9ACTN
Original site: A0A1G6PRV7_9ACTN 
ID   A0A1G6PRV7_9ACTN        Unreviewed;       907 AA.
AC   A0A1G6PRV7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-JUN-2019, entry version 11.
DE   RecName: Full=Histidine kinase {ECO:0000256|SAAS:SAAS00924638};
DE            EC=2.7.13.3 {ECO:0000256|SAAS:SAAS00924638};
GN   ORFNames=SAMN05421872_104123 {ECO:0000313|EMBL:SDC82758.1};
OS   Nocardioides lianchengensis.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=1045774 {ECO:0000313|EMBL:SDC82758.1, ECO:0000313|Proteomes:UP000199034};
RN   [1] {ECO:0000313|EMBL:SDC82758.1, ECO:0000313|Proteomes:UP000199034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.6858 {ECO:0000313|EMBL:SDC82758.1,
RC   ECO:0000313|Proteomes:UP000199034};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; FMZM01000004; SDC82758.1; -; Genomic_DNA.
DR   BioCyc; GCF_900101465:BLT76_RS08640-MONOMER; -.
DR   Proteomes; UP000199034; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00156; REC; 2.
DR   Gene3D; 1.20.120.160; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR036641; HPT_dom_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF01627; Hpt; 1.
DR   Pfam; PF00072; Response_reg; 2.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00448; REC; 2.
DR   SUPFAM; SSF47226; SSF47226; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52172; SSF52172; 2.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50894; HPT; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS01002602};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199034};
KW   Kinase {ECO:0000256|SAAS:SAAS00924871, ECO:0000313|EMBL:SDC82758.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01002785};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00110};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199034};
KW   Transferase {ECO:0000256|SAAS:SAAS00924820};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     12     34       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    179    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      208    260       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      282    504       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   DOMAIN      524    639       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN      659    776       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN      813    907       HPt. {ECO:0000259|PROSITE:PS50894}.
FT   REGION      776    795       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1G6PRV7}.
FT   COMPBIAS    781    795       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A0A1G6PRV7}.
FT   MOD_RES     575    575       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
FT   MOD_RES     708    708       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
FT   MOD_RES     852    852       Phosphohistidine. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00110}.
SQ   SEQUENCE   907 AA;  97074 MW;  DE28AE4F1CD0CA61 CRC64;
     MSLARQVGRV TLTGLLTVAL VALVNGAILG YLALSLDRDL ERATNGARAV RLAHLAMLDQ
     ETGLRAYLLT GQTSDLEPYS EGVVAAREQL EDAERYLDGD DRIAEMLAAQ QRASQRWTDD
     WVDEALGTGT ALAAQPGSPA KREFIDRGKA LFDDYRTVHD ELETYADQRR ADAQQRKTTV
     LAVGLVVEVL LLGGAAYVVG RQRRTLRAAV VEPVDELLVA IGRIRDGDLE PRPRGDAPDE
     LRDIGTGLDG MARALVERER ELVTARQDAE AANVAKSAFL ATMSHEIRTP MNAVIGMSGL
     LLASDLDDRQ RDYAETVQAS GDALLTIIND VLDFSKIESG ELDLEQHAFA LRECVESSLD
     LVAAQAAAQG IDLVAQIDPD VPAVVESDVT RVRQVLVNLL SNAVKFTSEG EVLVRVRVED
     GSDPDRPVLA LAVRDTGIGI PEDRMHRLFR SFSQVDSSTT RVYGGTGLGL AISQRLTEAL
     DGRLVVESEV GTGSTFTMVV PMRRAADGEE DRTRVAPAEL RGRHALVVDD NDTNRHILRA
     QLEAWGMHVV DFAHPAQALA TMAATPGALD LGVLDMHMPE LDGLDLARGL RELPAWADVP
     LLLLTSLGEP VREAASVRLV HLTKPVKAAS LRDTVAQLLG AHDLQAAVVE EPESLGRLRI
     LLAEDNTVNQ KVATLMLERL GQRPVVVANG EEALAAVHAA PYDLVLMDVH MPVMDGHEAT
     RRIRAELPVE RQPRIVAMTA GALVDDVDAS FAAGMDDHLS KPVRAQELAG ALRRVRSTTP
     TPAEPAPPPA EDLPPVLDPG ALDALTGHLG PDADAFRQRL VDAWVTDAGR QLAGLTAAVD
     AADAPAAADI AHSMRSASAS LGALLVAHRF AELETAARDG GDPATVAALA EAAAAEVERA
     RDALTRG
//
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