ID   A0A1G6R7Y0_9MICO        Unreviewed;       747 AA.
AC   A0A1G6R7Y0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SDD00628.1};
GN   ORFNames=SAMN05216410_2620 {ECO:0000313|EMBL:SDD00628.1};
OS   Sanguibacter gelidistatuariae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Sanguibacteraceae;
OC   Sanguibacter.
OX   NCBI_TaxID=1814289 {ECO:0000313|EMBL:SDD00628.1, ECO:0000313|Proteomes:UP000199039};
RN   [1] {ECO:0000313|EMBL:SDD00628.1, ECO:0000313|Proteomes:UP000199039}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISLP-3 {ECO:0000313|EMBL:SDD00628.1,
RC   ECO:0000313|Proteomes:UP000199039};
RA   Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; FMYH01000005; SDD00628.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6R7Y0; -.
DR   STRING; 1814289.SAMN05216410_2620; -.
DR   OrthoDB; 2365435at2; -.
DR   Proteomes; UP000199039; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199039};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        190..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        224..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        257..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        402..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        561..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        587..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        623..644
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        656..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        683..703
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          48..370
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          443..738
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   747 AA;  75752 MW;  18C693FEF0558D7E CRC64;
     MLSKRTSGVL RGLAILAVLG IWLGIGAVGG QAQGKLSSVQ TNDAAASLPS SAESTKAAEL
     SAAFVTSESL PGLVVITSAS GGALTPQQLT AVTDFAGSVA AIGVPGAGPQ DPQTIGDALT
     APPVVVPSKD GEAALITFSL DAALTDTPLA DGESLTPTVV TALREALAAE LADSGLTMWL
     TGPAGFVADL VVAFGGIDTV LLLVALVAVL LILGVVYRSP ILPFVVILTA VFALCLAGLV
     VYHLADAGTL VLNGQAQGIL SILVVGASVD YSLFVVARYR EELGRVAHPV QAMRVALRAS
     FEPVLASAGT VTAGLLCLLL SDLASNRSLG PVAAIGIVSA FLGAMTLLPA MLLVGGRRSR
     GAFWPRVPHL VMAEEATSAA VVPTTGLWAR IAHFVARHDR RVWVITALAL AACAAFVPTL
     NASGTSESAI FLTQVDSVDG EKVLAEHFDG GNVQPATVIA PEVDLDAVLA SATGVDGVVS
     AAAVTADSGT GQPGAPAQGP LTVIDGLVRI DVTTAAAADT QEGVETVAAL REAVHAVSAD
     ALVGGAAAER LDTQQAGTRD LQVIVPVVLA VILVILMLLL RSVLSAVLLM AANVLSFGAA
     LGVAAIVFNH VFGFPGADPT VPLYAFCFLV ALGVDYTIFL MTRVREETIT HGTREGVVRG
     LTVTGSVITS AGVVLAATFA ALGIIPLIFL AQIAFIVAFG VLLDTIVVRT LLVPALVHDI
     GGAVWWPSSL DRGAPEPTAI ATDTVVV
//