ID A0A1G6RVG4_9MICO Unreviewed; 900 AA.
AC A0A1G6RVG4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=SAMN05216410_2789 {ECO:0000313|EMBL:SDD08632.1};
OS Sanguibacter gelidistatuariae.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Sanguibacteraceae;
OC Sanguibacter.
OX NCBI_TaxID=1814289 {ECO:0000313|EMBL:SDD08632.1, ECO:0000313|Proteomes:UP000199039};
RN [1] {ECO:0000313|EMBL:SDD08632.1, ECO:0000313|Proteomes:UP000199039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISLP-3 {ECO:0000313|EMBL:SDD08632.1,
RC ECO:0000313|Proteomes:UP000199039};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
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DR EMBL; FMYH01000005; SDD08632.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6RVG4; -.
DR STRING; 1814289.SAMN05216410_2789; -.
DR Proteomes; UP000199039; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04863; MtLigD_Pol_like; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033649; MtLigD_Pol-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:SDD08632.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000199039}.
FT DOMAIN 619..742
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 319..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 97465 MW; 26D61A7F808BCACB CRC64;
MPTDSAREIV TIDGHSVTLT NLARVVYPQT GTTKAEVLAY FAAVAGPLVV HAAHRPATRK
RWVHGTGGPV FFQKNLEDSA PAWVHRREIQ HSDHVNTYPL VDDLATLTWL GQIGALEIHV
PQWRFGRTGA QHFPDRLVLD LDPGPGTGLA ECAEVARWAR TILTEMGMDL FPVTSGSKGI
HLYATLDGTQ SWEAASAVAH ELARALEADH GDLVVSEMKK SLRVGKVLVD WSQNNRNKTT
ITPYSLRGRE RPTVAAPRTW AELDDPGLAH LEADEVVSRF MHDGDLLAGL LAGGRAGLEP
TPGRLATFEQ GADRLAVYRS RRDPGRTPEP VPSADEPAIA GGSEAPIFVI QDHHARGHHF
DFRLERDGVL VSWALPKGEP VDPSTNHLAV QTEDHPLEYA NFSGTIPRGE YGAGTVSIWD
AGTYEVEKWR EGEEIIVVVH SSGVGGVDRG SRRLALIHTG HGGRGRSENS WLIHRMGGRG
VSRGGVQGLG LGGAGTRDTP AALADEPTAL PARPPEPMLA TPGTFADLER LEDSEAWAFE
MKWDGIRALA SVTGGIVRLT SRNGIDLTAT YPELAELSGC VGEDVLLDGE IVALNRSGRP
DFGLLQNRMN LTREAEVAAA RAEQPVDFMA FDLLHRGSRR MTTLGYDARR RALEEVLDEH
GRVHLPPAFT SGARAAIEAS LALGLEGVVA KRRSSTYRPG RRSPAWIKVK HVQTREVVVV
GWRTGKGSRA STLGSLLVAV PGDAVPNNLP PDNSTSHNSR PRDSQPGTII PIDIDRKAPG
ISPPDNSPPD DPTPHISVPD DAAPSQSARL RYAGRVGTGF TDKTLTRLRC ELDLIPHDTA
PLDDVPDADR IDAHWVVPDH VGEVSFAGWT GAGRLRHPVW LGWRPDKSPT EVTIEADESH
//
