ID A0A1G6S5A2_9BURK Unreviewed; 990 AA.
AC A0A1G6S5A2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=SAMN05192589_104329 {ECO:0000313|EMBL:SDD11355.1};
OS Paracidovorax valerianellae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Paracidovorax.
OX NCBI_TaxID=187868 {ECO:0000313|EMBL:SDD11355.1, ECO:0000313|Proteomes:UP000198781};
RN [1] {ECO:0000313|EMBL:SDD11355.1, ECO:0000313|Proteomes:UP000198781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16619 {ECO:0000313|EMBL:SDD11355.1,
RC ECO:0000313|Proteomes:UP000198781};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FMZC01000004; SDD11355.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6S5A2; -.
DR STRING; 187868.SAMN05192589_104329; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000198781; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd10567; SWIB-MDM2_like; 1.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR019835; SWIB_domain.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF02201; SWIB; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 2.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00151; SWIB; 1.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDD11355.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198781};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 3..138
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 907..988
FT /note="DM2"
FT /evidence="ECO:0000259|PROSITE:PS51925"
FT REGION 885..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 108507 MW; BC8C0B2F3EC33E33 CRC64;
MTKTLVIAEK PSVAQDIVRA LTPVAGKFDK HEDHFENDRY VVTSAVGHLV EIQAPEEFDV
KRGKWSFAHL PVIPPYFDLK PVDKTKSRLS AVVRQAKRKD VTELINACDA GREGELIFRL
IEQYAGGSKP DSKGLGKPVK RLWLQSMTPQ AIRDGFESLR SEQQMQGLAH AARSRSEADW
LVGINGTRAM TAFNSRDGGF FLTTVGRVQT PTLSLVVERE EKIRKFVSRD YWEVHAGFHA
EAGEYLGKWF NPQWKKSEDP EAKADRLWNH ADALAIAEAV RGKAASVTEE SKPTSQASPL
LFDLTSLQRE ANGKFGFSAK TTLALAQSLY ERHKALTYPR TDSRALPEDY LPVARDTFGM
LATSGMRHLA PFAQQALDGN YVKPTKRIFD NSKVSDHFAI IPTLQAPSGL SEAEQKLYDL
VVRRFMAVFF PSAEYMVTTR VSQVVNHSFK TEGKVLVRPG WLAIYGKEAA DEVEGAKDGD
KGQNLVPVKP GEMVRTEYAE PKGLKTKPPA RYSEATLLGA MESAGKQIDD EELRSAMQEK
GLGTPATRAA IIEGLLTEKY MLREGRELIP TAKAFQLMTL LRGLEVEELC RADLTGDWEF
KLSQMEKGLL SREAFMADIA KMTERMVKKA KEYDRDTIPG DYATLSAPCP NCGGVVKENY
RRYACVGKAG DGSDACGFSF GKSPAGRTFE TAEADRLLRD KKIGPLEGFR SKAGWPFTAE
VGIVYDDEAH NYKLEFDFGD DKNAEESGEL VDFSEQESLG ACPVCGAPVY EHGSNYVCSK
AVPTAAQATP SCTFKSGKII LQQPVERAQM SKLLATGKTD LLDKFVSMRT RRAFKAFLAW
DKEAGKVIFE FEQRESKFPP RKTFAAKTGA AGAAKTAAAA KKAAKPAAKT SSAAKSAAAK
KAPAAPKAPR KPAAGKAPSA LLAAVIGPEP VARPEAVKKM WDYIKANGLQ DATNKRAINA
DAKLRPVFGK DQVTMFELAG ILGKHLGGEA
//
