ID A0A1G6SVF3_9BURK Unreviewed; 751 AA.
AC A0A1G6SVF3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tyrosine-protein kinase Etk/Wzc {ECO:0000313|EMBL:SDD20207.1};
GN ORFNames=SAMN05444679_108202 {ECO:0000313|EMBL:SDD20207.1};
OS Variovorax sp. CF079.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=1882774 {ECO:0000313|EMBL:SDD20207.1, ECO:0000313|Proteomes:UP000198763};
RN [1] {ECO:0000313|EMBL:SDD20207.1, ECO:0000313|Proteomes:UP000198763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF079 {ECO:0000313|EMBL:SDD20207.1,
RC ECO:0000313|Proteomes:UP000198763};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FMZU01000008; SDD20207.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6SVF3; -.
DR STRING; 1882774.SAMN05444679_108202; -.
DR OrthoDB; 9808257at2; -.
DR Proteomes; UP000198763; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR005700; EPS_ExoP-like.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR NCBIfam; TIGR01005; eps_transp_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDD20207.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198763};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 548..701
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 280..321
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 751 AA; 81650 MW; 4C61E908050FC5BA CRC64;
MNSTLTPKTS PTSQIMSSAD EDDLDIGRYI DVLLSNKWLI AAITLVVFLI GATYAFLERP
IYESNMVVQV EDTGTGGKGI LSEAGGLIDV KTPANAEIEI IRSRMIAGQA VEATKLYIAA
SPRYVPYVGG WLARRATGLS EPGFLGLDGY VSGTERILVS KFDVPTHMEG GLFTVTAKAD
KQYTLDYPGM QQLTGTVGTP LKADTGSGPI ELTVTELAGK PGALFNLYRY AMLPTTIALQ
SSLILTERGK TSGIINVALQ DTDPFKLTRV LNAVGDQYVK QNIERKAAEA QKTLAFLDVQ
LPQFKKQLEA SEEVYNRYRN QKGTVAFSEE AALVLGQAVD RQTKLLDAQQ RRRELEARFT
SAHPAVQTLD SQIAALKTDM GEIQARIKGL PAIQQEAVRM ERDVKVNTEL YQQLLNNALQ
LRLVKEGKIG NVRVLDEAVV PQVPVKPNRK VIVAAALALG LFLGIVAAFV RSSFIEQRLR
DPHEVEADTG LPVFSTIPLS PAQSAIAKRR LSGATGVRLL AIESPDDPAV ESLRSLRTAM
QFAMLESPNN RVLITGPTPG VGKSFVTANF AALMAAAGKR TLLIDADLRR GHTHQYFGLQ
RHGGLSELIA GSLTVQQTVH RQVVPNLDFL ATGQLPPNPS ELLVSDSFKT ALERLSEQYD
LVVIDTPPVL VAADTSTVAT HAGTVLLVAR ADQSTMGELK ESTRRLAMGG KAATGVLLNA
MDVGRRAYAP YKYGRYRYTN YNYESILPEE Q
//
