ID A0A1G6U442_9GAMM Unreviewed; 680 AA.
AC A0A1G6U442;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase {ECO:0000313|EMBL:SDD36073.1};
GN ORFNames=SAMN04488509_102154 {ECO:0000313|EMBL:SDD36073.1};
OS Aquimonas voraii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Rhodanobacteraceae; Aquimonas.
OX NCBI_TaxID=265719 {ECO:0000313|EMBL:SDD36073.1, ECO:0000313|Proteomes:UP000199603};
RN [1] {ECO:0000313|EMBL:SDD36073.1, ECO:0000313|Proteomes:UP000199603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16957 {ECO:0000313|EMBL:SDD36073.1,
RC ECO:0000313|Proteomes:UP000199603};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; FNAG01000002; SDD36073.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6U442; -.
DR STRING; 265719.SAMN04488509_102154; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000199603; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199603}.
FT DOMAIN 309..481
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 486..577
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 680 AA; 73797 MW; F20E2D5F6C963488 CRC64;
MFDGLRFKHW RPELRDDRVV VLSFDRAESS VNTLAREVLE ELEQLVERIA IEKPKGVVMI
SGKSSGFVAG ADIAEFKTYH ERGTVFESIR YGQNVFQKLA ELPCPTVAAI HGFCMGGGTE
LSLACRYRVA STDDSTRIGL PEVKLGIYPG WGGSVRLPPL VGAPAAFDMM LTGRALSASN
ARAIGLIDKT CEPAVLLDTA LGLLKRGVKR PLKQRLTGWA TNWWPVRQAL APMLVKQVSR
KARKAHYPAP FALIETWRRS GGPIESRLVA EAKSVAKLAG TPTAQNLVRV FFLQERLKGL
GGKSHDIKHV HVVGAGVMGG DIAAWSALRG FETTLQDRSL EQIQPAIARA HTFYEKKLKR
EDKRAAAIAR LNADVDGAGV AKADLVIEAI FENLEAKRAL YAKIEESLPE SGLLTSNTSS
IPLTDLRAEL KRPAQFAGLH FFNPVSMMPL VEIVRHDGMD AETERRLAAF CRAIDKLPVP
VAGTPGFLVN RILMPYLLEA MTLYSEGVPG PVIDKAALAF GMPMGPIELA DTVGLDVAAS
VGKIMAEFLN LPIPSGLDGL LASGKRGRKD GQGFYTWENG RAKKPEVPKD YKAPEDLTDR
LVLAFVNEAV ACLHEGVVAD ADLLDAGVIF GTGFAPFRGG PIQYVRAEGA AKLKSRLEQL
AGRHGPRFNP RPGWDALIAG
//