ID A0A1G6VCG9_9BURK Unreviewed; 867 AA.
AC A0A1G6VCG9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Glucans biosynthesis glucosyltransferase H {ECO:0000256|ARBA:ARBA00020585, ECO:0000256|HAMAP-Rule:MF_01072};
DE EC=2.4.1.- {ECO:0000256|HAMAP-Rule:MF_01072};
GN Name=opgH {ECO:0000256|HAMAP-Rule:MF_01072};
GN ORFNames=SAMN05216345_11084 {ECO:0000313|EMBL:SDD51164.1};
OS Cupriavidus sp. YR651.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1855315 {ECO:0000313|EMBL:SDD51164.1, ECO:0000313|Proteomes:UP000198719};
RN [1] {ECO:0000313|Proteomes:UP000198719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR651 {ECO:0000313|Proteomes:UP000198719};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the biosynthesis of osmoregulated periplasmic
CC glucans (OPGs). {ECO:0000256|HAMAP-Rule:MF_01072}.
CC -!- PATHWAY: Glycan metabolism; osmoregulated periplasmic glucan (OPG)
CC biosynthesis. {ECO:0000256|ARBA:ARBA00005001, ECO:0000256|HAMAP-
CC Rule:MF_01072}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01072};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01072}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. OpgH
CC subfamily. {ECO:0000256|ARBA:ARBA00009337, ECO:0000256|HAMAP-
CC Rule:MF_01072}.
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DR EMBL; FMYZ01000010; SDD51164.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6VCG9; -.
DR STRING; 1855315.SAMN05216345_11084; -.
DR OrthoDB; 9775281at2; -.
DR UniPathway; UPA00637; -.
DR Proteomes; UP000198719; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009250; P:glucan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd04191; Glucan_BSP_MdoH; 1.
DR HAMAP; MF_01072; MdoH_OpgH; 1.
DR InterPro; IPR023725; Glucans_biosynth_gluTrFase_H.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43867; CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]; 1.
DR PANTHER; PTHR43867:SF5; GLUCANS BIOSYNTHESIS GLUCOSYLTRANSFERASE H; 1.
DR Pfam; PF13632; Glyco_trans_2_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01072};
KW Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_01072};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01072};
KW Reference proteome {ECO:0000313|Proteomes:UP000198719};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01072};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01072};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01072}.
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01072"
FT TRANSMEM 219..245
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01072"
FT TRANSMEM 537..564
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01072"
FT TRANSMEM 592..615
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01072"
FT TRANSMEM 627..648
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01072"
FT TRANSMEM 704..726
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01072"
FT DOMAIN 367..560
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF13632"
FT REGION 67..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96641 MW; 5515A2E9C09FA3B0 CRC64;
MELHLTPRLK QRPAQAAACE RYVDRLPASP ELRSELLADT PMPPVASVPT DGIEAPSAMI
QLQTRLAGRD PKDQEGIDFS QRSTPGGATY ASVSRRFSMA YGNPQTDGEP LLQRREDGTV
RVDTGPEPAR ESMVPRQWPP HVVTGGLRNL WRKMTGRPPI PETWDTLHDG PDAEGKWHPA
GSHRRWFLLA LVIGQTAVAT YFMAKVLPYH GADPLEIAIL ALFAILFSWV SAGFWTAMMG
FLVLAKGGDR HLISRSAAPD AAIDPAARTA VIMPICNEDV TRVFAGLRAT YESLERTGEL
AHFDFFVLSD SGNPDLRTAE HDAWMEICRA VGGFGRIFYR WRRHRVKRKT GNVADFCRRW
GSKYRYMIVL DADSVMSGDC LATLTRLMEA NPGAGIIQTA PLAVGRDTLY ARVQQFSTRV
YGPLFTAGLH YWQLGESHYW GHNAIIRIKP FMEHCALAPL PGKGPLSGEI LSHDFVEAAL
MRRAGWGVWI AYDLPGSFEE LPPNLLDEVK RDRRWCQGNL MNFRLWMKQG FHMVHRAVFL
TGIMAYLSAP LWLLFLLLST AALAKHALVP PEYFTQPYQL FPTWPEWHPE KALALFSATA
TLLFLPKLLS VLLLMKDARQ YGGVVRLVIS MLLEMAMSAL LAPTRMLFHT KFVIAAYSGW
GISWKSPPRE DAETTWGEAF RRHGWHTLLG LVWGGGVYWL SPGFIWWLLP IVGSLALSIP
LSVMLSRVSL GRAARRAGLF MIPEETIVPR EIVETQQHVE GAQDVPGFVD AVVDPVTNAL
MCATATARKI QPEPARLQHA SLVQHALTHG PQSLSAAQKH VLLGDPFALS RLHELVWGSP
LADAAWKETR VLMRRAANVL PLRPRAA
//
