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Database: UniProt
Entry: A0A1G6VQD5_9BURK
LinkDB: A0A1G6VQD5_9BURK
Original site: A0A1G6VQD5_9BURK 
ID   A0A1G6VQD5_9BURK        Unreviewed;       379 AA.
AC   A0A1G6VQD5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 6.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=SAMN05444679_111155 {ECO:0000313|EMBL:SDD55046.1};
OS   Variovorax sp. CF079.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=1882774 {ECO:0000313|EMBL:SDD55046.1, ECO:0000313|Proteomes:UP000198763};
RN   [1] {ECO:0000313|EMBL:SDD55046.1, ECO:0000313|Proteomes:UP000198763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF079 {ECO:0000313|EMBL:SDD55046.1,
RC   ECO:0000313|Proteomes:UP000198763};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FMZU01000011; SDD55046.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000198763; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198763};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198763};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       68    362       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   379 AA;  41114 MW;  D0671F7EB921F72E CRC64;
     MNRAATEYMT RLDDPLHDAE IGSRDSTIDT TRIDDVRIGA VRPLMTPALL QERVPVRDDT
     LALVEASRAA IADVLHGRSD RLVVVVGPCS IHDHDQALEY GHRLKAVADE LQDDLLIVMR
     TYFEKPRTTV GWKGYINDPH LDGSFAINEG LERARRLLLE LTTLGLPAGT EFLDLLSPQF
     IADLIAWGAI GARTTESQSH RQLASGLSCP VGFKNGTDGS IKVAADAILA ARAPHAFMGM
     TKMGMAAIFE TRGNDDCHVI LRGGKTPNYA AADVAATCEA LRALGLREQV MIDVSHGNSS
     KQYQRQIDVA HDVAGQIAAG ERRIAGVMIE SHLEEGRQDL VPGVPLRHGV SITDACIGFS
     QTVPVLQELA AAVRARRRL
//
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