ID   A0A1G6W394_9SPHN        Unreviewed;      1025 AA.
AC   A0A1G6W394;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Heavy metal efflux pump, CzcA family {ECO:0000313|EMBL:SDD60289.1};
GN   ORFNames=SAMN05444678_1178 {ECO:0000313|EMBL:SDD60289.1};
OS   Sphingomonas sp. YR710.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1882773 {ECO:0000313|EMBL:SDD60289.1, ECO:0000313|Proteomes:UP000198912};
RN   [1] {ECO:0000313|EMBL:SDD60289.1, ECO:0000313|Proteomes:UP000198912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YR710 {ECO:0000313|EMBL:SDD60289.1,
RC   ECO:0000313|Proteomes:UP000198912};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FMZJ01000017; SDD60289.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6W394; -.
DR   STRING; 1882773.SAMN05444678_1178; -.
DR   OrthoDB; 9758757at2; -.
DR   Proteomes; UP000198912; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF4; SLR6043 PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        333..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        473..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        528..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        860..879
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        963..982
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        994..1016
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1025 AA;  106608 MW;  89C70F80FE849CF3 CRC64;
     MLTALVRWSL SYPRLLVFAG LLFLAYGGIK LADARFDVFP EFVPAQADVQ TEAPGLTAEQ
     VEQLVTRPIE QAVNGAAGVA MVRSESIQGL SVVNISFAEG ADPFRARQVV SESLAEVAAT
     LPAGVDAPKV APLTSSTMDL LKVGFTSDRL SPAALRDTIQ YVVRPRMLAV PGVARATLYG
     GVISRIEVRV DPRALAARGI GFADVIAAVK SATGVIGGGY IDTPQQRILI ETRGQARGPA
     DIAATQVANH AGTITRIGDI ASVMAGPSPD IGGAIIMGKP GVLISMSSQY GANTLATTHA
     VERALAELEP ALAARGVNVQ HGLHRPANFI ETALINIAWD LLIGALLIAI VLFLFMRDLR
     TVLISFISIP LSLVAAVTVL SGLGYTINTM TLGGLAVALG VIVDDAVIDV ENIVRRLRGA
     AAGVPPVRTI LLASIEVRAP VIYATLVVAA VLVPVLLLHG LQGAFFSPLA AAFILATMAS
     LCVAIIVTPA LSLLLLGKVE LPPEPALLGR AKNAHAQWLR RVCERPRAAF AISGAAILAA
     LIGLLLFGGE LLPAFKEGHF VLAVSAQPGT SLRVMEDYGR NITRDLLAIP GVDTVEQQVG
     RAQGGEDNWG TERSEFHVEL KAGLSGSEQD RIEANIHTVL DSYPGLNTEV LTFLGDRIGE
     SLTGETAALA IGIYGADLDT LDRVAGEVAV VLKTIPGATD VQLKTPPSTP VVRVDLDLPK
     LAQFGLSATE ALATVQTAYQ GAATTQIYTD DRATDVAVTI PPELRGSPES VGRLLLRSSA
     GITVALGRVA HVYLAEGRTS IAHVGGRAQQ TVTANPDPSQ VARVTDAARQ SIAAKVKLPP
     GVYLEFSGTA EGAVAARNDI LANGAMAAAG VIALLVIAFG NGRSAALIMG AAPMALVGGV
     AAVALTGATL SLGALVGFVT LFGIAARNAI LLVAHVEQLV SEEGRPWSLD TLLLATRERV
     TPILMTALVT ALGLLPLAIG TGETGREIQG PMSIVILGGL ISSTAMSLLV LPPLMWRYWR
     PQTTA
//