ID A0A1G6WDJ5_9SPHI Unreviewed; 1194 AA.
AC A0A1G6WDJ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN05216464_102144 {ECO:0000313|EMBL:SDD63911.1};
OS Mucilaginibacter pineti.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1391627 {ECO:0000313|EMBL:SDD63911.1, ECO:0000313|Proteomes:UP000199072};
RN [1] {ECO:0000313|EMBL:SDD63911.1, ECO:0000313|Proteomes:UP000199072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=47C3B {ECO:0000313|EMBL:SDD63911.1,
RC ECO:0000313|Proteomes:UP000199072};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; FNAI01000002; SDD63911.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6WDJ5; -.
DR STRING; 1391627.SAMN05216464_102144; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000199072; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000199072};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..72
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1194 AA; 135578 MW; A9907B06638635B2 CRC64;
MPDFSHLHVH TQFSLLDGAA DISKLYKKAA ADGMKALAIT DHGNMFGVFK FVAEAGKHNV
KPIVGCEFYV VEDRHKKAFT KEKKDVRRHQ LMLAKNPEGY KNLVKLCSLG YMEGLYSKWP
RIDKELILKY HKGIIATTCC IGASVPQAIL RDTPEAAETE FKWWLDLFGE DFYIELQRHD
IPDQNTVNKV LLEYAKKYNV KIICSNDSHY VDQQDSNAHD ILLCVNTGDM QSTPIATDEE
GGRGYRFGFP NDQFYFKTQA EMGKLFNDLP ESLDNTNEIV DKVEVLKLKR DILLPNFVIP
PEFNIHTTAD ADTLNQWEYL KHLTFTGAKE RYIDISPEVE ERINFELFTI RTMGFAGYFL
IVADFIKHGR DIGVFIGPGR GSAAGSVVAY CTGITNIDPM KYNLLFERFL NPDRKSMPDI
DTDFDDAGRQ KVIDYVVEKY GKNQVAQIIT YGSMAARTSI QDVGRVLDMP LSEMNLIKKL
VPDTLGITLR EAIEQVPELK AILDGNDLRS QVLKEASKLE GSVRNTGVHA AGIIIAPYDL
TDIVPVAVAK DSDLLVTQYD GRVIEDAGVI KMDFLGLKTL TILKDALRMI KQNHGIHIDI
DYIPLDDKET YELYQRGDTN GTFQFESDGM QMYLRELKPD KFEDLIAMNA LYRPGPIEYI
PNFISRKHGR EPIVFDLADM EEYLGETYGI TVYQEQVMLL SQKLAGFSKG DADVLRKAMG
KKQIEVLNKM ESQFMDGAMA KGHPKDKLTK IWTDWKAFAQ YAFNKSHSTC YAFVAYQTAY
LKAHFPSEYM AAVLNNQNNM EKITFFMEEC RRMGVEVLGP DINESDLSFA VNRKGQVRFG
LTGVKGVGDK AVESIIEERI ANGPYLSVYD FARRSNTRSV NRKAYENLVQ GGGFDEFGYA
RAQFFAKTDT GTLTGVERLI KYANDYQNVQ SSSQSSLFGG SVASYVPEPA MPETEEWPLI
EKLKYEKTVI GIYLTGHPLD NYKVELERFC NSSISDLKLM QKARSGEGGE DIMGAFNELR
KRGEIRIGGL VSSVQHKMTK TGKPFGTFVL EDYNESYEFA LFGDDYVKFR NLMMEGYFLH
LKGNIEEKFR QKDNWDLRIL VMDLLSEMRD KHTKSLTVCI DINMLNSQLL DGIQHIINEN
NQKYPVKNCK LRFQIKDREE VMLVELASKT FKVNPSDDLM AGIFNLTNSQ PVLN
//
