ID   A0A1G6WF01_9RHOB        Unreviewed;      1118 AA.
AC   A0A1G6WF01;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   ORFNames=SAMN04488239_10943 {ECO:0000313|EMBL:SDD63646.1};
OS   Ruegeria marina.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Ruegeria.
OX   NCBI_TaxID=639004 {ECO:0000313|EMBL:SDD63646.1, ECO:0000313|Proteomes:UP000199628};
RN   [1] {ECO:0000313|Proteomes:UP000199628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.9108 {ECO:0000313|Proteomes:UP000199628};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; FMZV01000009; SDD63646.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6WF01; -.
DR   STRING; 639004.SAMN04488239_10943; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000199628; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014151; DNA_helicase_AddA.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; TIGR02784; addA_alphas; 1.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199628}.
FT   DOMAIN          4..477
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          496..782
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         25..32
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1118 AA;  123096 MW;  DE4D8C770C365D14 CRC64;
     MTQRNEATEA QFRASHPAAS TWLAANAGSG KTKVLTDRVA RLLLNGVEPQ HILCLTYTKA
     AASEMQNRLF KRLGEWAMLG DVPLRAQLSD LGVHGSIDSA RLAHARTLFA RAIETPGGLK
     IQTIHSFCAA LLRRFPLEAR VSPQFAEMED RAAALLREEI VEDLAQGPQA PLVEMVARYI
     TDTGFDSLTA AICQHRAGFA HPMDWEHLAE AFGLPPAFDE GALLEQVYLG GEMELIRSIL
     PALAGSGPND QKAGAKLARF DGPTLDGLTV LEDVLLTGAT AKEPFAAKIG GFPTKGPRQG
     ALAGQMPQLE ALMLRVEAAR DRRLALTAAR KSLALHRFAA AFLPEYERRK QLRGWLDFDD
     LIQKARQLLS DPGVAAWVLY RLDGGIDHIL VDEAQDTSPE QWGVIEKLAQ EFTSGEGARA
     GVERTIFVVG DKKQSIYSFQ GADPDAFDRM QEEFGRKLRE SGSNLEDLTL EYSFRSSSAI
     LGLVDLVFEN RAEAGFRKES LHRAFKSDMP GRVDLWPVVE KVEDDEDGDW TDPVDRPGSR
     HHTVILAERV ARQIKSMIDN GETIPIDGET PGTFLRRPVQ PGDFLILVQR RSDLFAEIIR
     ACKAAGLPIA GADRLKVGAE LAVRDLAALL SFLATPEDDL SLATVLKSPL FGWSEQQLFD
     LAHRRTDRYL WAALRSRKNE FPRTLAVLDD LRSQTDFLRP YDLIERILTR HDGRRKLLGR
     LGSEAEDGIN ALLSQALAYE RSDIPSLTGF LVWMQTDDLE IKRQMTGVGN MVRVMTVHGS
     KGLEAPIVIL PDTAQRRAQR DAEIIKAGDL PLWRVSRDDS PSVLSAARDS AQARETNERL
     RLLYVALTRA EKWLIVAAAG DIGKDGSSWY SMVADAMARA GAAQVEGQDF LRLEHGEWER
     AQLTEARTLN TGTQPLPDWV HHLAPERIEI KPVSPSDLGG AKALPGEAGL DEEAAKLRGT
     RLHLLLEHLP PVDQTAWAEI CARLLPDMQE AERSKLLAEA HAVLTSPELA PVFAAGTLAE
     VPVSATIGAR RMHGVIDRLV ITATEVQVID FKSNAVVPDT PEACPEGLLR QMGAYAQALA
     QIYPAHQIRT GFLWTRTARM MWLPHDLVTA ALGRTQIS
//