ID A0A1G6WUD9_9PROT Unreviewed; 956 AA.
AC A0A1G6WUD9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316, ECO:0000256|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000256|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156, ECO:0000256|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000256|HAMAP-Rule:MF_00205};
GN ORFNames=SAMN05421720_101255 {ECO:0000313|EMBL:SDD68807.1};
OS Rhodospira trueperi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Rhodospira.
OX NCBI_TaxID=69960 {ECO:0000313|EMBL:SDD68807.1, ECO:0000313|Proteomes:UP000199412};
RN [1] {ECO:0000313|EMBL:SDD68807.1, ECO:0000313|Proteomes:UP000199412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700224 {ECO:0000313|EMBL:SDD68807.1,
RC ECO:0000313|Proteomes:UP000199412};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000, ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00205}.
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DR EMBL; FNAP01000001; SDD68807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6WUD9; -.
DR STRING; 69960.SAMN05421720_101255; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000199412; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00205};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00205}; Reference proteome {ECO:0000313|Proteomes:UP000199412};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00205};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_00205}.
FT DOMAIN 364..600
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 605..942
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT ZN_FING 745..771
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 646..653
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
SQ SEQUENCE 956 AA; 104547 MW; 4F43D5288E968D66 CRC64;
MTPPATHTIR VTGAREHNLK GIDVTLPRDR LVVITGLSGS GKSSLAFDTI YAEGQRRYVE
SLSAYARQFL ELMQKPDVES IEGLSPAISI EQKTTSRNPR STVGTVTEIH DYMRLLWARV
GVPHSPATGL PIESQTVSQM VDAIMAMGEG TRLYLLAPII RGRKGEYRKE LGELRKRGFQ
RVKVDGEVHD IADVPALDKK RKHDIAVVVD RVIVKSGLET RLADSVETAL GLSDGLLITE
DASSGEETVF SAKFACPVSG FTIEEIEPRL FSFNNPFGAC PACDGLGVKL YFDPDLVVPN
PDKTLRDGAI APWSSYGQPA PYYAQALASV ATHYGGDMDT PWRDMPERAR EVLLHGSGDE
IIALHFDDGS RSYRTEKPFE GVIPNIARRW RETESAGMRE ELSRYQASHP CESCEGFRLK
PEALAVKIDS RHIGEISDLS ISAALDWFAG LEERLRPKDR EIAHRILREI NERLGFLTSV
GLTYLTLSRT SGTLSGGESQ RIRLASQIGS GLTGVLYVLD EPSIGLHQRD NDRLLATLKR
LRDLGNTVIV VEHDEDAIRA ADHLVDMGPG AGVHGGTIVA EGTPEEVMAN PASLTGQYLT
GGRTVTVPDD RRPGNGKALR IEGARGNNLQ DLTVDIPLGT FTCVTGVSGG GKSTLIVETL
YKALARHLHG ARELPAPHDA IKGVEHIDKI VDIDQSPIGR TPRSNPATYT GAFTPIRDWF
ANLPDAKARG YKPGRFSFNV KGGRCEACQG DGVIKIEMHF LPDVYVTCDV CKGKRYNRET
LEILFRGKSI ADVLDMTVEE AAEVFKAVPV IRDKMELLQR VGLGYVHLGQ QATTLSGGEA
QRVKLAKELS RRATGRTLYI LDEPTTGLHF EDVRKLLEVL HHIVDQGNTV LVIEHNLEVI
KTADHIIDLG PEGGSGGGRL VAQGTPEAVA ETRESYTGQY LKGHLLEAAA RKRRPA
//
