ID   A0A1G6X4S4_9ACTN        Unreviewed;       599 AA.
AC   A0A1G6X4S4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:SDD73180.1};
GN   ORFNames=SAMN05421872_110164 {ECO:0000313|EMBL:SDD73180.1};
OS   Nocardioides lianchengensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=1045774 {ECO:0000313|EMBL:SDD73180.1, ECO:0000313|Proteomes:UP000199034};
RN   [1] {ECO:0000313|EMBL:SDD73180.1, ECO:0000313|Proteomes:UP000199034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.6858 {ECO:0000313|EMBL:SDD73180.1,
RC   ECO:0000313|Proteomes:UP000199034};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; FMZM01000010; SDD73180.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G6X4S4; -.
DR   STRING; 1045774.SAMN05421872_110164; -.
DR   OrthoDB; 5240528at2; -.
DR   Proteomes; UP000199034; Unassembled WGS sequence.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 2.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199034}.
FT   DOMAIN          13..191
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          194..290
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          319..497
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          500..596
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   599 AA;  64172 MW;  E44C6196FB8E4429 CRC64;
     MTETTATART LTTVGVVGLG TMGAGIAEVL ARHGYAVVGV EKDEEALARG RQYLEHSTAR
     AVKREKLTEA EQAELLGRIS LTTELSDLAG AGFVVEAVVE SMELKKQIFR ELDAIVAPDA
     ILATNTSSLS VTDLSTATAR PGRVVGVHFF NPAPVQDLVE IVRTVVTEDT VLGEVKALVE
     ALGKNPVVCG DKAGFIANTL LFGYLNHAVA MYEGRYATRE DIDAAMRYGC GYPMGPLALL
     DLIGLDTAYE ILETMYRQGR DRLHAPSPIL KQMVTAGLLG RKTGRGFYTY EAPDSPVVVA
     DALTPSADDE PALRHEITTV GVVGTGTMAT GIIEVFAKSG YDVTYVGRSQ EKVDGVVAAI
     TKSFDKQIQR GRSTEEKKVE VLSRLTGSAS LDDLAAVDLV VEAIAEDLAI KTTLFENLDD
     ICKPGAILAT TTSSLPIIAM AKVTSRPQDV IGMHFFNPAT IMKLVEVVST VATDDAVTET
     TRALCAKVGK VAVTCGDRAG FIVNALLFPY LNDAVKMLEA HYATADDIDT AMKQGCALPM
     GPFELLDVVG NDVSLAIQRE LYLEFREPGF APAPLLEHLV TAGYLGRKTK RGFRDYSVR
//