ID A0A1G6XUA4_9ACTN Unreviewed; 430 AA.
AC A0A1G6XUA4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase {ECO:0000313|EMBL:SDD81758.1};
GN ORFNames=SAMN05421872_11190 {ECO:0000313|EMBL:SDD81758.1};
OS Nocardioides lianchengensis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=1045774 {ECO:0000313|EMBL:SDD81758.1, ECO:0000313|Proteomes:UP000199034};
RN [1] {ECO:0000313|EMBL:SDD81758.1, ECO:0000313|Proteomes:UP000199034}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.6858 {ECO:0000313|EMBL:SDD81758.1,
RC ECO:0000313|Proteomes:UP000199034};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FMZM01000011; SDD81758.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6XUA4; -.
DR STRING; 1045774.SAMN05421872_11190; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000199034; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008764; F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0051301; P:cell division; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008360; P:regulation of cell shape; IEA:InterPro.
DR Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR InterPro; IPR005762; MurD.
DR NCBIfam; TIGR01087; murD; 1.
DR PANTHER; PTHR43692; UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE; 1.
DR PANTHER; PTHR43692:SF1; UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:SDD81758.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000199034}.
FT DOMAIN 111..222
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
SQ SEQUENCE 430 AA; 44058 MW; 0236FA0B19E6B683 CRC64;
MIGAGTGWRG LAGLRVGVWG VGVEGSASLR RLAADGVTPY AVVDRVAGDG VLALDAGGLD
RLLECDVVVK SPGISPYDEP ARTLTAAGVR LAGGLGLWLE DAPRDRVACL TGTKGKSTAT
AIAGALATGL GSRAFVGGNI GRAPWEPGVE EADVYLVETS SYQAHDVTTG PRVVAVTSLS
QDHLVWHHGY DGYVRDKLSL CTRPGVETVV APAADAELER YADLLGPHVL RVAEAPAPWA
DGLGLIGRHN LRNALLAQAV LAALGVPGAE DEGALAAAAA SYTPLPSRLT RVGAVGDVEF
VDDSLSTNTL PTLAAVASFP GRRVALLVGG QDRGIDYAPL AAGLADVPDL LVLTLPDNGP
RIASTIRAVA PGVPVEECPD LASAVRRGHA FAAPDGVVLL SPAAPSFGVF RDYAERAEVF
TAAMRALPHG
//
