ID A0A1G6XUE4_9SPHI Unreviewed; 361 AA.
AC A0A1G6XUE4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SAMN05216464_102653 {ECO:0000313|EMBL:SDD81333.1};
OS Mucilaginibacter pineti.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1391627 {ECO:0000313|EMBL:SDD81333.1, ECO:0000313|Proteomes:UP000199072};
RN [1] {ECO:0000313|EMBL:SDD81333.1, ECO:0000313|Proteomes:UP000199072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=47C3B {ECO:0000313|EMBL:SDD81333.1,
RC ECO:0000313|Proteomes:UP000199072};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; FNAI01000002; SDD81333.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6XUE4; -.
DR STRING; 1391627.SAMN05216464_102653; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000199072; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDD81333.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199072};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 42..90
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 103..320
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 361 AA; 41061 MW; BCAB52A57BC503D3 CRC64;
MNRLLKKLEK IGRDPKITAK AVGLRYVSDS SSGYTRKKSG KGWSYYDADG VLVKDKELIS
RFNGLVIPPA YTNVWISPYD NGHLQFTGTD VAGRKQYRYH AHWNQIRNQS KYHRLQTFAA
YLPAIRAQVD KDLTRHNLDH EKVVALVVRL MELTSIRVGN ESYKKLYGSF GLTTLQNRHI
KIEGSNIKFE FKGKKGVFHK VALQSRRLAK LVKQCRDIPG KELFQYYNEA GERCSIGSGD
INNYLKEITG EDFTAKDFRT WSGSVSALYA FKEAGEFNSV TECRKKIVSV LDEVAVNLGN
TRTVCKKYYV HPSVIKSYEE GTIFKYISKL DEDSDVKAAE LNIAEKALIK LLETEKLAEA
S
//
