ID A0A1G7ABW5_9NOCA Unreviewed; 3100 AA.
AC A0A1G7ABW5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Fatty acid synthase {ECO:0000313|EMBL:SDE12291.1};
GN ORFNames=SAMN05444580_110125 {ECO:0000313|EMBL:SDE12291.1};
OS Rhodococcus tukisamuensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=168276 {ECO:0000313|EMBL:SDE12291.1, ECO:0000313|Proteomes:UP000199417};
RN [1] {ECO:0000313|EMBL:SDE12291.1, ECO:0000313|Proteomes:UP000199417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 11308 {ECO:0000313|EMBL:SDE12291.1,
RC ECO:0000313|Proteomes:UP000199417};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
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DR EMBL; FNAB01000010; SDE12291.1; -; Genomic_DNA.
DR RefSeq; WP_072844868.1; NZ_FNAB01000010.1.
DR STRING; 168276.SAMN05444580_110125; -.
DR Proteomes; UP000199417; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.3320; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16073; SAT; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199417}.
FT DOMAIN 2556..3011
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3100 AA; 324132 MW; FD17AF2835D442FB CRC64;
MTIDESTPAG QGNGAGRSRF APSAGPAKSP LRDRFLSGEP YALAFGGQGA AWLSPLEELI
RDNGLEPDMT ALVNEAAALL APVAQDLLVV RPAGFDPIGW ILEQDVVDEG AAPAGPSAAA
LTSASVSLPG VLLTQIAALK SLRLQGLDPE RTPPVAVIGH SQGLLAAESV ATGGNADASL
LAIAQLIGAA AVLVGRRRGV LGGAERAPML AVSDVDPARM QAIVDEVGRG LDSECAAVMA
IRNGRRRVVL SGPPAQLARV QQRAEQVAAD EARERDAKKR GGAVFSPVFE PLAVEIGFHH
PALADAVDTV GAWAVRCGLD ADLATRLACA CLTDPVDWVV EVDNAVDAGA SWILDLGPGD
LLTRMTVNAL RGRGVGIVAA STRGGQRNLL TPGAAPEVQK AWTEFAPTLV TLPDGKVATS
TAFTRLTGRS PILLAGMTPT TVDAKIVAAA ANAGHWAELA GGGQVTEQIF TDRVAELQTL
LEPGRAVQFN SLFLDPYLWK LQLGGKRLVQ RARAAGAPID GVIVTAGIPE LDEAVALIEE
LGEAGISHVA FKPGTVAQIR SVIRIANEVP DYPVIVHIEG GKAGGHHSWE DLDDLLLTTY
AELRARPNLV ICVGGGIGTP ERAAEYLTGR WSEAAGYPAM PVDGILVGTA AMATLEATTS
PEVKQLLVDT PGTPDWVGAG TAAGGMASGR SQLGADIHEI DNAASRTGRL LDEVAGDADA
VAERRDEIVA ALDGTAKPYF GDVATMSYER WLRRYLELAV GIDSAKVFDC GTDWSEAYAD
ATESVWLDVT WRDRFAQMLQ RAEARLHRND RGPIQTLFAD EATLERPEAA LCALTAAYPD
AADTVLHPAD VPFFTSLCKI AGKPVNFVPV IDKDVRRWWR SDSLWQAHDP RYSADQVCVI
PGTVAVAGIT RVDEPVGELL DRFERATTDE LLGAGVTPTE VTARRHGTQA RGLLAVVLAS
PDVLWASRLT RNPVHRLGDL AAWTVEETAA THATTGAVLR AVDAETAELS VPLVAGRAVT
IRLTVPASTR DGGAPVVTDA DAEAAMSALL GVAAGQDLPA VKNATARLNV AWIPDLVADH
AGVTASGLPE SLIPGAGAVP DVIVGACWPA VFAVLGAATT SEGIHAIEGM LDLVHLDHAV
NLVDAVPADA AVLTVKAEGI SVVDTDMGRV VEVHVEVGAM RGEEGTAAPT FATMVERFAI
RGRTGKGELA DPVRAGGSLT DAATDTPRRR RRQATIVAPR HMGAFARVSG DHNPIHTSDA
AALLAGLGSP IVHGMWLSAA AQQVVTAVDP TATVPARRLT AWTARFLGMV RPGAEIDVRV
DRTAFDGGAE VIEVGCRVDG ELVMVASGRT DAPKTVYAFP GQGIQRPGMG LDARARSKAA
REIWDRADKH TRQALGFSIL AVVRDNPTVL KARGVTHKHP DGVLHLTQFT QVAMAVLGVA
QVAELREAGA FVEDSLLAGH SVGEYNALAA VAGVLPLEAV LEVVFQRGSA MHALVPRDAA
GRSNYRLAAI RPSQIGVADE DLAEFVAGVA AETGEFLEIV NLNLRGSQYA IAGTVAGLDA
LEQEIDRKRA ETGGKRAYIQ IPGIDVPFHS TVLRGGVDDF RERLLHLLPQ EIDPAILIGR
YIPNLVPKPF NLGRDFVQEI ADLVPSEPLA EVLADFDAWA ARPSDLCRVV LAELLAWQFA
SPVRWIETQD LLFGDESDGG LGVERFVEIG LGAVPTVANL ASQTLKLPGR FGNPVEVLNI
EREAGVVFST DTDPAPVEDD EPEAPVAETA APAAVAAPAP AAAPAAPSGG PRPDDIAFAA
SDATAVLIGL WTKLRPDQVG PADTIEALCD GVSSRRNQLL VDLGAELSLG AIDGAADADM
GALAVTVNKL ARTYKPFGPV LTDSLNDHLR KVFGPSGKRP AAIAERVTKV WELGAGWASH
VTAEVALGTR DGSSVRGGSL GGLHEGALSD GAAVDAVIDA AVQSVASRRG AAVSMPAAGG
GAGGTVDAAA LGEFTEHITG RNGVLASAAR LVLEQLGLAD EAVSAAPDAD TELVDLVSAE
LGSDWPRLVA PAFDARRAVL VDDRWATARE DLARLWLESD ASALETVNFT GAGKTVGAHA
AWWQQRAQAE GRAELATTYA RIAADAVASD DQAAEWADQV AVVTGASKGS IAASVAGKLL
RGGATVFVTT SRLDSERLGF YRKLYRANAR AGAALWVVPA NMASYSDVDA LIEWIGSEQT
ETAGGAKKLV KEAVTPTMLF PFAAPRVGGE LSDAGARAEM EMRVLLWSVE RLIGGLSKIG
YDRDVDTHLH VVLPGSPNRG LFGGDGAYGE SKAALDAVVM RWNAERNWAE RVTLVHALIG
WVRGTGLMGG NDPMVEAVEA KGVRTWSTEE MAEQLLAGCT PETVRAAATA PVQLDLTGGL
ADVDLDLVAL ARDAADAEKA SAASESAADE DGTIAALPAP PRLAAALPEM VWPELDVNPS
DLVVIVGAGE LGPYGSSRTR FEMEVDEELS AAGVLELAWN TGLLTWENDP VAGWYDTESG
ELVPEAEIAE RYHDAVVERC GIRTYVDEGA MVDNTAPLLT SVFLDNDLTF VVGSEAEAKA
FVESDPEHTV AAAVPDSGDW QVTRRAGTEI RVPRKAKLTR TVGGQIPTGF DVTKWGIPAD
MAGSVDRVGL WNLVTTVDAF LTGGFTPSEL LRWVHPSTVA NTQGTGMGGM TSMRSLYIDT
LLGESRANDI LQEALPNVIA AHVVQSYVGG YGAMVHPVAA CATAAVSVEE GVDKIRLGKA
QLVVAGGFDD LGIEGIVGFG DMSATAKSAD MTAKGIDERR FSRANDRRRG GFVESAGGGT
ILLARGDLAL EMGLPVLGVV AWAGSFADGV HTSIPAPGIG ALGAGRGGQD SQLALSLNAL
GVTADDISVV SKHDTSTAAN DPNEAELHER LAAALGRSEG SPLFVVSQKS LTGHAKGGAA
AFQLIGLCQV LGQGIVPPNR SLDCVDPKMA EFEHLVWPRE AMRFGGSFPL KAGLLTSLGF
GHVSGLIAVV HPQAFVESIP AAKRGDYLAQ AQERTLAGQR RLASAMCGGA DLYERPADRR
FGGDSVPAQA ARQLEADMLL TCEARLGDDD VYRSGLPGCQ
//
