ID   A0A1G7BL05_9FLAO        Unreviewed;       934 AA.
AC   A0A1G7BL05;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Topoisomerase-4 subunit A {ECO:0000313|EMBL:SDE27764.1};
GN   ORFNames=SAMN05421636_104203 {ECO:0000313|EMBL:SDE27764.1};
OS   Pricia antarctica.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Pricia.
OX   NCBI_TaxID=641691 {ECO:0000313|EMBL:SDE27764.1, ECO:0000313|Proteomes:UP000199109};
RN   [1] {ECO:0000313|EMBL:SDE27764.1, ECO:0000313|Proteomes:UP000199109}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23421 {ECO:0000313|EMBL:SDE27764.1,
RC   ECO:0000313|Proteomes:UP000199109};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; FNAO01000004; SDE27764.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G7BL05; -.
DR   STRING; 641691.SAMN05421636_104203; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000199109; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDE27764.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199109};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          58..492
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          866..934
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          457..484
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        26..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        891..927
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   934 AA;  106312 MW;  B92C87961F480EA2 CRC64;
     MDENDELNLN AGEEGNPKEN KGEAEDQNLN AGQEDASADS RSDAPTEEQP QNTEDALTRV
     SGMYKDWFLD YASYVILERA VPAIEDGFKP VQRRIMHSLK DLDDGRYNKV ANVVGHTMQY
     HPHGDASIAD AMVQIGQKEL LIDTQGNWGN ILTGDSAAAS RYIEARLSKF ALEVVFSPKI
     TEWQQSYDGR KKEPVNLPVK FPLLLAQGAE GIAVGLSTKI MPHNFIEVID ASIKHLEGKR
     FKLFPDFPTA GIIDVTNYND GLRGGKIRVR AKIAQHTKTT LIISEIPYGT NTSSLIDSIL
     KANDKGKIKI KKIEDNTAAE VEIMVHLPPG ISPDKTIDAL YAFTACESSI SPLGCIIEDN
     KPLFIGVTEM LRRSTDATVD LLRQELEIQL AELEEQWHFA SLERIFIENR IYRDIEEEET
     WEGVIAAIDK GLKPFTKNLR RAVTEEDIIR LTEIRIKRIS KFDLDKAQQN LDNLEQRIAE
     VKHHLAHLVE FAISYFVGLK ERYGKGRERK SEIRIFEDIE ATKVVIRNTK LFVNREEGFV
     GTSLKRDEYV ADCSDIDDII AFTKEGKMMI FKVDSKVFVG KGIIYVAIFK KKDKRTIYNM
     VYRDGKSGAT YIKRFNVTSI TREKLYDVGK GKPGTIVYYF SGNPNGEAET VTVNLRQSGK
     IKKLKWDIDF ADVLIKGRNT KGNIVSKYPV KRIELKEKGL STLKPRKLWF DETVRRLNID
     DRGEFMGEFR SGDRLLIVNQ SGLVKTVTPE LTLRFDDDIV ILEKWIPEKP LSAIYWEGEK
     ELFYIKRFLI ENPDKEENIL TDHPKSYLER FLTDYLPRVE VVFAKKRGQE RKDNWVVHLE
     EFISVKGITA MGNQLTKEKV LEINGLSPLP YEPPEPQKAE DIEVKEEEEI EDDANISKAI
     GRSDKNPLED PNVLEDPSKK PKKNNGDDQP TLFD
//