ID A0A1G7C7E7_9SPHI Unreviewed; 863 AA.
AC A0A1G7C7E7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=SAMN05216464_105318 {ECO:0000313|EMBL:SDE35251.1};
OS Mucilaginibacter pineti.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1391627 {ECO:0000313|EMBL:SDE35251.1, ECO:0000313|Proteomes:UP000199072};
RN [1] {ECO:0000313|EMBL:SDE35251.1, ECO:0000313|Proteomes:UP000199072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=47C3B {ECO:0000313|EMBL:SDE35251.1,
RC ECO:0000313|Proteomes:UP000199072};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; FNAI01000005; SDE35251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7C7E7; -.
DR STRING; 1391627.SAMN05216464_105318; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000199072; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014143; NHEJ_ligase_prk.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000199072};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 314..449
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 863 AA; 98495 MW; 6BA817805C8C282B CRC64;
MGLTEYAKKR NFKKTAEPAG GKPGSDKLLF VVQKHAASHL HYDFRLEVKG VLKSWAVPRG
PSMDPEERRL AMAVEDHPYD YKDFEGIIPK GQYGGGTVIV WDEGWYEPAS DEKLKDKAAK
EHWMMSNYYK NALKIKLHGH KLKGDFILIK FKEDKYEGGW RLIKADDEYA TKADILLKDK
SVKSKLTVEQ MGKKQGAEVW NSNRAPEKPE PDLKTQGIRK AMPHSVKPML CTLTKEVVPD
DDYLYEVKWD GYRIISYIEN KKVRMDSRSA LDYTKKYPPV AKALAALGHD AVLDGEVVVF
NEEGKPDFDA LQTFNGHDAP INYCVFDLLW LDGYHLMNLP LTDRKAILKE LVADNDVLRF
SESFDDGVAL YQQALDLDLE GIVAKRKDSA YVPDARDNRW LKTPTRKRQE FVIGGWAESD
KSRSFRSLLF GAYNNKGEFE WIGRSGGGYK QSEMPGILAR LQQLEIEKTP FINKVLDTKG
AKIHWVKPEL VANFEFATWT KTGRIRKPAT FLGFRKDKKA SQVVREVPLS DDQEEQIKEA
PKPVIADTDS NWPKIDSKKI NSEREFEFAG QTVTMNNIEQ ELWRGITKAR LITYYHSICP
YILPYLKDRP LSLHIKQDGA NAPGFYIKDM EGRQPDYLDI FSDQRRHKKK GKRDQIDYAV
CNNEAALLYL INLGNIDLNP WSSTTGNPQE PDLISIDLDP SDEDFGKAIK TAQAAKRVFD
QYKLQSLVKT SGKTGIHIFI PCQGFTYPQA RTIAEKLCDE IAKQVPEIAT TEVSIDHRGD
KLFVDPSQND YADTLAAAYS VRPYKHPTVS TPLDWKEVKD KLDPGKFTID TLPERLEKKG
DLFADLLNDQ WRKANTKILK EML
//