ID A0A1G7EBG4_9FLAO Unreviewed; 333 AA.
AC A0A1G7EBG4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SAMN05421636_106119 {ECO:0000313|EMBL:SDE60998.1};
OS Pricia antarctica.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Pricia.
OX NCBI_TaxID=641691 {ECO:0000313|EMBL:SDE60998.1, ECO:0000313|Proteomes:UP000199109};
RN [1] {ECO:0000313|EMBL:SDE60998.1, ECO:0000313|Proteomes:UP000199109}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23421 {ECO:0000313|EMBL:SDE60998.1,
RC ECO:0000313|Proteomes:UP000199109};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; FNAO01000006; SDE60998.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7EBG4; -.
DR STRING; 641691.SAMN05421636_106119; -.
DR Proteomes; UP000199109; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDE60998.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199109};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 22..70
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 84..300
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 333 AA; 38960 MW; 70859A500A33BF54 CRC64;
MKKIREIDDS AMCISRKKRG KGYSFYDENG KLIKDQKVLK RLRGMVIPPM WQGVMICRFD
DGHIQAIGRD AKNRKQYIYH SVYEKQQQEA KFKKMLDFSK LLPKIREKAH KDLDVKGWDK
HKLVALIILI LDEYGIRIGN KEYKKQNESY GLTTLRRKHL NIEDDELLLS FMGKSHQEQE
VHIDDETLVP FIKEVANLPG YEIFRYRDEQ KNFHDVDSDD VNEYIAEYMG PDFSSKDFRT
WSANRLAVEC YPLALEELED GSRKKFSNIV IKMVAAELGN TPTVCRDYYV HPALFRSIDE
KTLPDPNPFK EVKTAFGLSA SEKLARKVIE ESY
//
