ID A0A1G7EEH3_9ACTN Unreviewed; 474 AA.
AC A0A1G7EEH3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Hemolysin, contains CBS domains {ECO:0000313|EMBL:SDE62074.1};
GN ORFNames=SAMN04489747_3921 {ECO:0000313|EMBL:SDE62074.1};
OS Auraticoccus monumenti.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Auraticoccus.
OX NCBI_TaxID=675864 {ECO:0000313|EMBL:SDE62074.1, ECO:0000313|Proteomes:UP000198546};
RN [1] {ECO:0000313|EMBL:SDE62074.1, ECO:0000313|Proteomes:UP000198546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MON 2.2 {ECO:0000313|EMBL:SDE62074.1,
RC ECO:0000313|Proteomes:UP000198546};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LT629688; SDE62074.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7EEH3; -.
DR STRING; 675864.SAMN04489747_3921; -.
DR OrthoDB; 110231at2; -.
DR Proteomes; UP000198546; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF17; UPF0053 INNER MEMBRANE PROTEIN YFJD; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000198546};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..188
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 207..267
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 275..332
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 423..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 50782 MW; 3CA68EC19727AD07 CRC64;
MSQDHVVLLA VAGLLAVVAA LLASVESALT SFSKARASEL VEEGRPGASR LAVLVADPAP
YLNTALFLRI IAEITAVVLV ADVVFGELER TWLQWLVAAG SMILVSFVLW GVAPRTLGRQ
HADRVACAAA GPLSALTTVL GPVPQLLILL GNALTPGRGF SDGPFNSEAE LRELVDMAEA
NELIEARERR MIHSVFELGD TIVKEVMVPR TEIVSIEQDR SLRQAVSLAL RSGYSRIPVV
GEGLDDVVGV VYLKDLMRRQ FDNPRAETSE RVAKVMRPVT WVPDSKPVDA LLREMQLTRS
HLVMVVDEFG GTAGLATIED ILEEIVGEIV DEYDREVDPV TELGPGRYRV TSRLAVDEVG
ELFGLRLDDE DVDSIGGLLA KHLGRVPIAG STVQVEGLEL VAERGSGRRK GIGTVLVQRV
PEEDQTAVTD DASAPAATAL RTDDATAPDP GAPGDPAETT PPMIGAPSHD RHHA
//
