ID A0A1G7ES74_9FLAO Unreviewed; 615 AA.
AC A0A1G7ES74;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN05421855_102120 {ECO:0000313|EMBL:SDE66512.1};
OS Ulvibacter litoralis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Ulvibacter.
OX NCBI_TaxID=227084 {ECO:0000313|EMBL:SDE66512.1, ECO:0000313|Proteomes:UP000199321};
RN [1] {ECO:0000313|EMBL:SDE66512.1, ECO:0000313|Proteomes:UP000199321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16195 {ECO:0000313|EMBL:SDE66512.1,
RC ECO:0000313|Proteomes:UP000199321};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; FNBA01000002; SDE66512.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7ES74; -.
DR STRING; 227084.SAMN05421855_102120; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000199321; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000199321}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 432..574
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 615 AA; 68828 MW; 13C5F9E0945750A9 CRC64;
MTDIIQLLPD HVANQIAAGE VVQRPASVVK ELLENAIDAG ASTITLVIKD AGKTLVQVID
DGAGMSTTDA RLCFERHATS KIKSAEDLFS LNTKGFRGEA LASIAAIAHV ELKTKTEASE
VGTKIVIEGS QVVSQDAVVT AKGTTISVKN LFYNIPARRN FLKSNTVEMR HIIDEFHRVA
LAHPQVGFTM MNNGSDVFQL PQSNSRQRIV SIFGAKTNEK LVPVTEETEI LKISGFVIKP
DFARKSRGEQ FFFVNDRFIK SSYLHHAVLA AFEGLIKDGM NPGYFLFLDV DPKSIDINIH
PTKTEIKFDD EHAMYAMLRS TIKHSLGQFS IAPVLDFNRD AGFDTPYEYS KKSPVTPTIE
VDRSFNPFKK EPSQANIKFP YQREKTSSWE SLYVGLKDDD SELQSGFQNI EFESEEVTGK
LFEKETEEVG QTTFQLHNKY IVSPIKTGMM IIHQHLAHQR VLYEELLKNI TVQEAVSQQL
LFPLQFHFSK PDIEILKKIQ EQLEQTGFVF SSLKEEAFEI SGIPVSIVES SVGTVLEQLI
KDIKEEVPDA GFSQNDLLAK SMAKSMAVKT GVPLNREERE HLVNQLFACK EPSVAPNNKT
VLITMNVNDF DKKFS
//
