ID   A0A1G7FHC1_9EURY        Unreviewed;       254 AA.
AC   A0A1G7FHC1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=NAD-dependent deacetylase {ECO:0000313|EMBL:SDE75314.1};
GN   ORFNames=SAMN05216218_101195 {ECO:0000313|EMBL:SDE75314.1};
OS   Halorientalis regularis.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Halorientalis.
OX   NCBI_TaxID=660518 {ECO:0000313|EMBL:SDE75314.1, ECO:0000313|Proteomes:UP000199076};
RN   [1] {ECO:0000313|EMBL:SDE75314.1, ECO:0000313|Proteomes:UP000199076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBRC-M 10760 {ECO:0000313|EMBL:SDE75314.1,
RC   ECO:0000313|Proteomes:UP000199076};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNBK01000001; SDE75314.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G7FHC1; -.
DR   STRING; 660518.SAMN05216218_101195; -.
DR   OrthoDB; 728at2157; -.
DR   Proteomes; UP000199076; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd01407; SIR2-fam; 1.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR11085:SF12; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Transcription {ECO:0000256|ARBA:ARBA00023015};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}.
FT   DOMAIN          1..254
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   ACT_SITE        124
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         132
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         135
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         157
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         160
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ   SEQUENCE   254 AA;  27126 MW;  4BEA2D33D9B5CE2D CRC64;
     MSVDEPDVRA VAQAVRDAES VVALTGAGVS TASGIPDFRG EDGIWERHDP MDFHIDRFRS
     DPEGFWRDRV KLQASAFDDG NVAPNAAHEA LAGLESAGHL DTVVTQNIDG LHQDAGSEDV
     IEIHGSAARV VCRDCNQRFD AEPAMARARD GDLPPTCDDC DGTLKPDTVL FGEQLPEHAL
     MQSQAKAESA GVFLAVGSSL TVEPAASLPR VAAERGATLV LVNLESTPLS GRADFDFRAD
     VTEALPQLRR AVEE
//